Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.47 |
| ▸ | APLNR | P35414 | 2/20 | 0.47 |
| ▸ | CCR6 | P51684 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494550 | 1.00 | AGTR1 (0.48) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4973717 | 0.78 | RAB9A (0.56) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL13713054 | 0.78 | AGTR1 (0.54) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4500717 | 0.78 | AGTR1 (0.51) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4500725 | 0.78 | AGTR1 (0.51) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4494547 | 0.77 | AGTR1 (0.50) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4494656 | 0.76 | CYP1A2 (0.50) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4490408 | 0.76 | RAB9A (0.48) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4488114 | 0.74 | RAB9A (0.46) | AGTR1KMT2AHSP90AA1CXCR5APLNR | |
| SCHEMBL4497221 | 0.72 | AGTR1 (0.51) | AGTR1KMT2AHSP90AA1CXCR5APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585883-B2 | Substituted pyridines and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| EP-1817303-A2 | SUBSTITUTED PYRIDINES WITH ACTIVITY ON SYK KINASE | Rigel Pharmaceuticals, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| US-20060178407-A1 | Substituted pyridines and their uses | RIGEL PHARMACEUTICAL, INC. (US) | 2006-08-10 | — | — | US | disclosed |
| WO-2006050480-A2 | SUBSTITUTED PYRIDINES WITH ACTIVITY ON SYK KINASE | RIGEL PHARMACEUTICALS, INC. (US) | 2006-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178407-A1 | Substituted pyridines and their uses | KIT, CPA3, CMA1 | AGTR1 3568/4885KMT2A 1075/4885HSP90AA1 3864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.