Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | WNT1 | P04628 | 2/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 5/20 | 0.45 |
| ▸ | STK16 | O75716 | 5/20 | 0.45 |
| ▸ | BMP2K | Q9NSY1 | 5/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.44 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.44 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.44 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.44 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486691 | 0.91 | AAK1 (0.61) | AAK1DYRK1AWNT1LIMK1GAK | |
| SCHEMBL4486019 | 0.89 | WNT1 (0.51) | AAK1DYRK1AWNT1 | |
| SCHEMBL4503708 | 0.86 | FGFR1 (0.59) | DYRK1AWNT1 | |
| SCHEMBL4492127 | 0.86 | GSK3B (0.53) | DYRK1AWNT1 | |
| SCHEMBL12886064 | 0.86 | AAK1 (0.58) | AAK1GAKSTK16BMP2KMKNK1 | |
| SCHEMBL4488792 | 0.85 | AAK1 (0.68) | AAK1GAKSTK16BMP2KMKNK1 | |
| SCHEMBL12886382 | 0.84 | AAK1 (0.58) | AAK1GAKSTK16BMP2KMKNK1 | |
| SCHEMBL4479634 | 0.84 | AAK1 (0.67) | AAK1GAKSTK16BMP2KRIOK3 | |
| SCHEMBL4495070 | 0.83 | HDAC6 (0.53) | — | |
| SCHEMBL4491352 | 0.83 | AAK1 (0.66) | AAK1GAKSTK16BMP2KMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |