Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | BCL3 | P20749 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503708 | 0.92 | FGFR1 (0.59) | HDAC6HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL4486921 | 0.91 | HDAC6 (0.55) | HDAC6HDAC1HDAC2HDAC8KDM4E | |
| SCHEMBL4492127 | 0.90 | GSK3B (0.53) | ALDH1A1POLBLMNAKDR | |
| SCHEMBL4505268 | 0.86 | ABL1 (0.62) | HDAC6HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL4486019 | 0.86 | WNT1 (0.51) | ALDH1A1HSD17B10FGFR1KDR | |
| SCHEMBL4476091 | 0.85 | HDAC1 (0.52) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4495432 | 0.84 | CHEK1 (0.57) | MMP12HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL4494664 | 0.83 | AAK1 (0.59) | — | |
| SCHEMBL4501959 | 0.83 | FGFR1 (0.59) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4559844 | 0.83 | HDAC6 (0.62) | HDAC6HDAC1HDAC2HDAC8FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |