Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492127 | 0.92 | GSK3B (0.53) | WNT1DYRK1APDGFRBFLT1KDR | |
| SCHEMBL4490154 | 0.91 | MEN1 (0.50) | WNT1DYRK1AGSK3BFGFR1AAK1 | |
| SCHEMBL4494664 | 0.89 | AAK1 (0.59) | WNT1DYRK1AAAK1 | |
| SCHEMBL4503708 | 0.89 | FGFR1 (0.59) | WNT1DYRK1AHSD17B10FGFR1ALDH1A1 | |
| SCHEMBL4495070 | 0.86 | HDAC6 (0.53) | HSD17B10KDRFGFR1ALDH1A1 | |
| SCHEMBL4495432 | 0.84 | CHEK1 (0.57) | WNT1DYRK1AMAPK1GSK3BSHMT2 | |
| SCHEMBL4505268 | 0.83 | ABL1 (0.62) | WNT1DYRK1AHSD17B10KDRFGFR1 | |
| SCHEMBL4480187 | 0.83 | GSK3B (0.59) | GSK3BFGFR1 | |
| SCHEMBL4491062 | 0.82 | GSK3B (0.55) | WNT1DYRK1AGSK3BAAK1GSK3A | |
| SCHEMBL4494624 | 0.82 | GSK3B (0.53) | GSK3BFGFR1AAK1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |