Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.64 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489218 | 0.83 | SCN9A (0.61) | SCN9ASCN10ACYP2C9CYP3A4CYP2D6 | |
| SCHEMBL27629488 | 0.80 | SCN9A (0.43) | SCN9ASCN10ANTRK1PHGDH | |
| SCHEMBL4504115 | 0.79 | SCN9A (0.63) | SCN9ASCN10ACYP2C9SCN5ATRPA1 | |
| SCHEMBL2678185 | 0.78 | PHGDH (0.60) | PHGDH | |
| SCHEMBL3435638 | 0.76 | CA12 (0.54) | SCN9ATRPA1NTRK1 | |
| SCHEMBL2832477 | 0.76 | SCN9A (0.58) | SCN9ASCN10A | |
| SCHEMBL4485194 | 0.75 | PHGDH (0.46) | PHGDH | |
| Hydrochloric Acid SCHEMBL29833674 | 0.74 | SCN9A (0.57) | SCN9ASCN10A | |
| SCHEMBL14564398 | 0.74 | SCN9A (0.64) | SCN9ASCN10ACYP2C9TRPA1CYP3A4 | |
| SCHEMBL19936469 | 0.73 | KMO (0.43) | SCN9ASCN10ATRPA1NTRK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589116-B2 | Biaryl substituted pyrazoles as sodium channel blockers | MERCK & CO. INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20060183785-A1 | Biaryl substituted pyrazoles as sodium channel blockers | MERCK SHARP & DOHME CORP. | 2006-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183785-A1 | Biaryl substituted pyrazoles as sodium channel blockers | TRPV1, TRPA1, TRPV3 | SCN9A 78/4885SCN10A 64/4885CYP2C9 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.