Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 20/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 20/20 | 0.71 |
| ▸ | HTR1B | P28222 | 20/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 20/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 20/20 | 0.71 |
| ▸ | DRD2 | P14416 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.69 |
| ▸ | HTR7 | P34969 | 2/20 | 0.69 |
| ▸ | DRD3 | P35462 | 2/20 | 0.69 |
| ▸ | HTR2C | P28335 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511474 | 0.84 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7720235 | 0.83 | HTR1A (0.78) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6991351 | 0.83 | HTR1A (1.00) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL4498500 | 0.83 | HTR1A (0.74) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL4500989 | 0.82 | HTR1A (0.71) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6990308 | 0.81 | HTR1A (1.00) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6989359 | 0.81 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6997613 | 0.81 | HTR1A (1.00) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL6993256 | 0.81 | HTR1A (1.00) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL13934464 | 0.81 | HTR1A (0.75) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7491729-B2 | 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof | ABBOTT GMBH & CO. KG (DE) | 2009-02-17 | — | — | US | disclosed |
| US-7491729-B2 | 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof | ABBOTT GMBH & CO. KG (DE) | 2009-02-17 | — | — | US | disclosed |
| EP-1572698-B1 | 3-SUBSTITUTED 3,4-DIHYDRO-THIENO¬2,3-D PYRIMIDINE-4-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF | ABBOTT GMBH & CO KG (DE) | 2008-07-02 | — | — | EP | disclosed |
| US-20060142317-A1 | 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142317-A1 | 3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof | HTR3C, DRD3, HTR4 | HTR1A 32/4885ADRA1D 61/4885HTR1B 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.