Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.60 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1238598 | 0.86 | AURKA (0.59) | HTR3ANPY5RAURKANUDT1MAPT | |
| SCHEMBL16702345 | 0.80 | PARP1 (0.49) | HTR3AHTR2CHTR2ASLC6A4HTR3E | |
| SCHEMBL531762 | 0.76 | HTR3A (1.00) | HTR3ANPY5RHTR2CSLC6A4MAPT | |
| SCHEMBL2240925 | 0.75 | HTR3A (0.60) | HTR3AHTR2CHTR2ASLC6A4MAPT | |
| SCHEMBL17533872 | 0.75 | HTR3A (0.53) | HTR3AHTR2CHTR2ARAB9AKDM4E | |
| SCHEMBL2507996 | 0.75 | HTR3A (0.49) | HTR3AAURKAHTR2CHTR2APLD1 | |
| SCHEMBL7600366 | 0.74 | HTR3A (0.59) | HTR3ANPY5RAURKAHTR3EHTR3B | |
| SCHEMBL28343931 | 0.73 | NUDT1 (0.49) | NPY5RAURKANUDT1MAPTRAB9A | |
| SCHEMBL2524318 | 0.72 | HTR3A (0.52) | HTR3AHTR2CHTR2AALDH1A1HTR3E | |
| SCHEMBL3075702 | 0.71 | HTR3A (0.88) | HTR3ANPY5RMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534796-B2 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-19 | — | — | US | claimed |
| US-20060189617-A1 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-08-24 | — | — | US | claimed |
| CN-101704781-B | Preparation method of amino pyridine bromide compound | UNIV JIANGSU POLYTECHNIC | 2012-05-30 | — | — | CN | disclosed |
| CN-101704781-A | Preparation method of amino pyridine bromide compound | UNIV JIANGSU POLYTECHNIC | 2010-05-12 | — | — | CN | disclosed |
| US-7582636-B2 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7534796-B2 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-19 | — | — | US | disclosed |
| US-20060270848-A1 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-11-30 | — | — | US | disclosed |
| US-20060189617-A1 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189617-A1 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | GNRHR, PRLHR, FSHR | HTR3A 245/4885NPY5R 18/4885AURKA 1768/4885 |
| US-20060270848-A1 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor | GNRHR, PRLHR, FSHR | HTR3A 433/4885NPY5R 90/4885AURKA 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.