Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.59 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | SI | P14410 | 4/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11198421 | 0.85 | HRH4 (0.58) | HTR3ANPY5RAURKAHTR6HRH4 | |
| SCHEMBL20449682 | 0.77 | PARP1 (0.56) | HTR3AHTR6PARP1 | |
| SCHEMBL17697629 | 0.77 | CRBN (0.59) | HTR3AHTR6PARP1 | |
| SCHEMBL7417787 | 0.77 | NPY5R (0.47) | NPY5RAURKAHRH4MGAMGAA | |
| SCHEMBL1066810 | 0.76 | HTR3A (0.56) | HTR3ANPY5RADRB1HTR6PIM1 | |
| SCHEMBL5621808 | 0.76 | PARP1 (0.72) | PARP1 | |
| SCHEMBL28034227 | 0.75 | HTR3A (0.51) | HTR3ANPY5RHTR6PIM1PARP1 | |
| SCHEMBL28034117 | 0.75 | HTR3A (0.48) | HTR3ANPY5RHTR6PIM1PARP1 | |
| SCHEMBL5506042 | 0.75 | HTR3A (0.48) | HTR3ANPY5RHTR6HRH4PIM1 | |
| SCHEMBL7463681 | 0.74 | ADRB1 (0.44) | HTR3AADRB1HRH4PIM1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |