SCHEMBL4495989

SCHEMBL4495989

Nc1c2c(nc3ccccc13)CCCC2=O

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.82
ACHE P22303 8/20 0.65
BCHE P06276 6/20 0.65
HSD17B10 Q99714 6/20 0.59
ALDH1A1 P00352 5/20 0.59
GLA P06280 2/20 0.59
HPGD P15428 2/20 0.59
GAA P10253 1/20 0.59
TSHR P16473 4/20 0.58
CYP1A2 P05177 3/20 0.58
KCNH2 Q12809 3/20 0.58
CYP2D6 P10635 2/20 0.58
CHRM2 P08172 2/20 0.58
ADRA2A P08913 2/20 0.58
ADORA3 P0DMS8 2/20 0.58
CHRM1 P11229 2/20 0.58
SLC6A2 P23975 2/20 0.58
OPRM1 P35372 2/20 0.58
CACNB4 O00305 1/20 0.58
CACNA1A O00555 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8984092 0.98 KDM4E (0.80) KDM4EACHEBCHEHSD17B10ALDH1A1
SCHEMBL9875563 0.90 KDM4E (0.68) KDM4EACHEBCHEHSD17B10ALDH1A1
SCHEMBL9874322 0.82 ACHE (0.60) KDM4EACHEBCHEHSD17B10ALDH1A1
SCHEMBL9685408 0.81 ACHE (0.61) KDM4EACHEBCHEHSD17B10ALDH1A1
SCHEMBL8791193 0.81 KDM4E (0.57) KDM4EACHEBCHEHSD17B10ALDH1A1
SCHEMBL10847043 0.80 ACHE (0.62) KDM4EACHEBCHEGRIN1GRIN2A
SCHEMBL9873371 0.80 ACHE (0.68) KDM4EACHEBCHECHRM1GRIN1
SCHEMBL28984980 0.80 ACHE (0.66) KDM4EACHEBCHEGRIN1GRIN2A
SCHEMBL10848027 0.80 ACHE (0.66) KDM4EACHEBCHEALDH1A1APP
SCHEMBL9068077 0.80 ACHE (0.66) KDM4EACHEBCHEALDH1A1GRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115947686-A 9-amino-3, 4-dihydroacridine-1 (2H) -ketone compound and application thereof 浙江工业大学 2023-04-11 CN claimed
EP-0179383-B1 9-AMINO-1,2,3,4-TETRAHYDROACRIDIN-1-OL AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-05-29 EP claimed
US-4631286-A MEMORY ENHANCERS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1986-12-23 US claimed
EP-0179383-A2 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1986-04-30 EP claimed
CN-115947686-B 9-Amino-3, 4-dihydro-acridine-1 (2H) -ketone compound and application thereof 浙江工业大学 2024-11-12 CN disclosed
CN-115947686-A 9-amino-3, 4-dihydroacridine-1 (2H) -ketone compound and application thereof 浙江工业大学 2023-04-11 CN disclosed
EP-2681554-B1 BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR BECTON DICKINSON CO (US) 2017-08-09 EP disclosed
US-9459187-B2 Blood collection device containing lysophospholipase inhibitor BECTON, DICKINSON AND COMPANY (US) 2016-10-04 US disclosed
US-20140030754-A1 BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR BECTON, DICKINSON AND COMPANY (US) 2014-01-30 US disclosed
US-20130209985-A1 SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS BECTON, DICKINSON AND COMPANY 2013-08-15 US disclosed
US-8252814-B2 Agents and crystals for improving excretory potency of urinary bladder TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-08-28 US disclosed
US-20090264467-A1 Agents and crystals for improving excretory potency of urinary bladder ISHIHARA YUJI 2009-10-22 US disclosed
US-4994452-A Memory disfunction HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1991-02-19 US disclosed
US-4839364-A ALZHEIMER*S DISEASE; CHOLINESTERASE INHIBITORS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-06-13 US disclosed
US-4835275-A Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-05-30 US disclosed
US-4835275-A Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-05-30 US disclosed
US-4754050-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1988-06-28 US disclosed
US-4695573-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-09-22 US disclosed
US-4631286-A MEMORY ENHANCERS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1986-12-23 US disclosed
EP-0179383-A2 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1986-04-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264467-A1 Agents and crystals for improving excretory potency of urinary bladder ACHE, BCHE, PDE7A KDM4E 562/4885ACHE 1/4885BCHE 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.