Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | BCHE | P06276 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495989 | 0.81 | KDM4E (0.82) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8984092 | 0.79 | KDM4E (0.80) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL9875444 | 0.76 | ACHE (0.62) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL8786616 | 0.76 | KDM4E (0.60) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL9874848 | 0.76 | ACHE (0.64) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL28984972 | 0.76 | ACHE (0.62) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL9876043 | 0.76 | ACHE (0.63) | ACHEKDM4EBCHEGRIN1GRIN2A | |
| SCHEMBL9210645 | 0.76 | ACHE (1.00) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL9874322 | 0.75 | ACHE (0.60) | ACHEKDM4EBCHEHSD17B10ALDH1A1 | |
| SCHEMBL9873371 | 0.73 | ACHE (0.68) | ACHEKDM4EBCHEGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | claimed |
| EP-0273176-B1 | FUSED HETEROCYCLIC TETRAHYDROAMINOQUINOLINOLS AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-06-24 | — | — | EP | disclosed |
| EP-0273176-A2 | Fused heterocyclic tetrahydroaminoquinolinols and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4753950-A | MEMORY ENHANCEMENT, ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-06-28 | — | — | US | disclosed |