Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480639 | 0.92 | MAPT (0.42) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4494108 | 0.91 | ALDH1A1 (0.43) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4489143 | 0.88 | FLT1 (0.42) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4490242 | 0.86 | ALDH1A1 (0.42) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4500127 | 0.85 | CYP19A1 (0.44) | EEF2KMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4488977 | 0.84 | MAPT (0.42) | MAPTCYP1A2CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL4507950 | 0.84 | NR3C1 (0.46) | MAPTNR3C1PGRPOLBRAB9A | |
| SCHEMBL4490058 | 0.83 | MALT1 (0.41) | MAPTHTTNR3C1PGRCNR1 | |
| SCHEMBL4498936 | 0.82 | FLT1 (0.44) | MAPTCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4508036 | 0.82 | KDM1A (0.46) | MAPTHTTALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589120-B2 | N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application | SANOFI-AVENTIS (FR) | 2009-09-15 | — | — | US | claimed |
| US-20070287744-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2007-12-13 | — | — | US | claimed |
| EP-1841754-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | Sanofi-Aventis (FR) | 2007-10-10 | — | — | EP | claimed |
| WO-2006077320-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2006-07-27 | — | — | WO | claimed |
| US-7589120-B2 | N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application | SANOFI-AVENTIS (FR) | 2009-09-15 | — | — | US | disclosed |
| US-20070287744-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2007-12-13 | — | — | US | disclosed |
| EP-1841754-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | Sanofi-Aventis (FR) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077320-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | SANOFI-AVENTIS (FR) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287744-A1 | N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION | TPMT, TXNRD2, ARG2 | EEF2K 3255/4885MAPT 4238/4885CYP1A2 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.