Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | GALR3 | O60755 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13958577 | 0.82 | P2RX7 (0.57) | P2RX7P2RX3 | |
| SCHEMBL13958572 | 0.81 | P2RX7 (0.56) | P2RX7P2RX3 | |
| SCHEMBL13958609 | 0.81 | P2RX7 (0.58) | P2RX7P2RX3 | |
| SCHEMBL13958619 | 0.81 | P2RX7 (0.58) | P2RX7P2RX3MEN1KMT2A | |
| SCHEMBL13958587 | 0.81 | P2RX7 (0.57) | P2RX7SMN1; SMN2P2RX3 | |
| SCHEMBL13958566 | 0.81 | P2RX7 (0.61) | P2RX7P2RX3MEN1KMT2A | |
| SCHEMBL13958573 | 0.81 | P2RX7 (0.60) | P2RX7P2RX3 | |
| SCHEMBL13958590 | 0.81 | P2RX7 (0.60) | P2RX7P2RX3MEN1KMT2A | |
| SCHEMBL13958563 | 0.80 | P2RX7 (0.59) | P2RX7P2RX3 | |
| SCHEMBL13958567 | 0.80 | P2RX7 (0.54) | P2RX7P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018133-A1 | Novel Adamantane Derivatives | FORD RHONAN | 2009-01-15 | — | — | US | disclosed |
| US-20050090524-A1 | Novel adamantane derivatives | ASTRAZENECA AB (SE) | 2005-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018133-A1 | Novel Adamantane Derivatives | ADRA1A, ADORA1, ADRA1D | P2RX7 554/4885HTT 2174/4885GALR3 765/4885 |
| US-20050090524-A1 | Novel adamantane derivatives | ADRA1A, ADORA1, ADRA1D | P2RX7 732/4885HTT 2335/4885GALR3 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.