Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13678571 | 0.92 | KDM5A (0.38) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3521563 | 0.89 | MAPK14 (0.55) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4504739 | 0.87 | MAPK14 (0.46) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4982763 | 0.85 | MAPK14 (0.50) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4512780 | 0.85 | MAPK14 (0.50) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4381139 | 0.82 | MAPK14 (0.46) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3526249 | 0.81 | MAPK14 (0.49) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL4510193 | 0.80 | OPRK1 (0.40) | MAPK14ALDH1A1OPRK1APLNR | |
| SCHEMBL3524202 | 0.80 | MAPK14 (0.59) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL13678570 | 0.77 | MAPK14 (0.42) | MAPK14MAPK11ROCK2MAPK12STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885MAPK11 404/4885ROCK2 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.