Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.63 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4509219 | 0.83 | MMP2 (0.53) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL4508086 | 0.82 | MMP2 (0.55) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL2460732 | 0.79 | MMP2 (0.58) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL4511731 | 0.78 | CYP19A1 (0.43) | MMP2MMP13CYP19A1 | |
| SCHEMBL4499300 | 0.77 | MMP2 (0.50) | MMP2MMP3ALDH1A1MAPTCYP19A1 | |
| SCHEMBL410754 | 0.74 | MMP2 (0.61) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL21660969 | 0.73 | MMP2 (0.66) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL1618099 | 0.72 | ALDH1A1 (0.56) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL5725197 | 0.72 | ALDH1A1 (0.61) | MMP2MMP3ALDH1A1MAPTMMP1 | |
| SCHEMBL21595642 | 0.72 | MMP2 (0.67) | MMP2MMP3ALDH1A1MAPTMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099162-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | US | disclosed |
| US-20080319198-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080249086-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-10-09 | — | — | US | disclosed |
| US-20080207899-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | US | disclosed |
| US-20080146812-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
| US-7354917-B2 | Oxabispidine compounds and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2008-04-08 | — | — | US | disclosed |
| US-20070259864-A1 | Novel Oxabispidine Compounds and Their Use in the Treatment of Cardiac Arrhythmias | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| EP-1765831-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123747-A1 | NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099162-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | MMP2 4639/4885MMP3 4705/4885ALDH1A1 445/4885 |
| US-20080207899-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | MMP2 4639/4885MMP3 4705/4885ALDH1A1 445/4885 |
| US-20070259864-A1 | Novel Oxabispidine Compounds and Their Use in the Treatment of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | MMP2 4639/4885MMP3 4705/4885ALDH1A1 445/4885 |
| US-20080146812-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | MMP2 4639/4885MMP3 4705/4885ALDH1A1 445/4885 |
| US-20080319198-A2 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | MMP2 4639/4885MMP3 4705/4885ALDH1A1 445/4885 |
| US-20080249086-A1 | Novel Oxabispidine Compounds And Their Use In The Treatment Of Cardiac Arrhythmias | RYR1, KCNH1, CACNA1E | MMP2 4639/4885MMP3 4705/4885ALDH1A1 445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.