Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492923 | 0.82 | PKM (0.55) | PKMCYP2C19NPC1MAPTNPSR1 | |
| SCHEMBL4500668 | 0.79 | CYP2C19 (0.48) | PKMCYP2C19PPARGPPARANPC1 | |
| SCHEMBL4974416 | 0.77 | KDM4E (0.54) | PKMNPC1MAPTNPSR1CYP1A2 | |
| SCHEMBL115820 | 0.75 | CYP1A2 (0.65) | CYP2C19NPC1MAPTCYP1A2GAA | |
| SCHEMBL27859334 | 0.74 | CYP2C19 (0.44) | CYP2C19PPARGPPARANPC1MAPT | |
| SCHEMBL2983425 | 0.74 | PPARA (0.54) | CYP2C19PPARGPPARAGSTP1GSTM2 | |
| SCHEMBL2983423 | 0.74 | PPARA (0.54) | CYP2C19PPARGPPARAGSTP1GSTM2 | |
| SCHEMBL27589045 | 0.74 | PPARA (0.54) | CYP2C19PPARGPPARAGSTP1GSTM2 | |
| SCHEMBL30102053 | 0.73 | RAB9A (0.54) | PKMCYP2C19NPC1MAPTCYP1A2 | |
| SCHEMBL28966351 | 0.73 | RAB9A (0.54) | PKMCYP2C19NPC1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7585883-B2 | Substituted pyridines and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20060178407-A1 | Substituted pyridines and their uses | RIGEL PHARMACEUTICAL, INC. (US) | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178407-A1 | Substituted pyridines and their uses | KIT, CPA3, CMA1 | PKM 2002/4885CYP2C19 385/4885PPARG 1805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.