Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | PTPRC | P08575 | 1/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPRB | P23467 | 1/20 | 0.52 |
| ▸ | PTPRE | P23469 | 1/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22396553 | 0.86 | MAPK14 (0.51) | ALDH1A1KDM4EHPGDMAPK14PTPRC | |
| SCHEMBL27980556 | 0.86 | MAPK14 (0.51) | MAPK14PTPRCPTPN2PTPN1PTPRB | |
| SCHEMBL4493257 | 0.83 | PTPRC (0.49) | ALDH1A1KDM4EHPGDMAPK14HSD17B10 | |
| SCHEMBL14465321 | 0.81 | KDM4E (0.50) | ALDH1A1KDM4EHPGDMAPK14TUBB4A | |
| SCHEMBL6422791 | 0.81 | PTPRC (0.63) | ALDH1A1KDM4EHPGDHSD17B10PTPRC | |
| SCHEMBL21070463 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDMAPK14HSD17B10 | |
| SCHEMBL1891113 | 0.80 | IMPDH2 (0.50) | ALDH1A1KDM4EHPGDMAPK14HSD17B10 | |
| SCHEMBL31664243 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDMAPK14HSD17B10 | |
| SCHEMBL12869677 | 0.79 | MAOB (0.48) | KDM4EMAPK14TUBB4ATUBBTUBA3C | |
| SCHEMBL6421819 | 0.79 | PTPRC (0.55) | ALDH1A1KDM4EHPGDMAPK14HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488744-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488744-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488744-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-7304048-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304048-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7304048-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-12-04 | — | — | US | disclosed |
| US-7291613-B2 | Inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291613-B2 | Inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-7291613-B2 | Inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1178983-B1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS INC (US) | 2007-10-24 | — | — | EP | disclosed |
| US-20030144520-A1 | Indole-type derivatives as inhibitors of p38 kinase | MAVUNKEL BABU J (US) | 2003-07-31 | — | — | US | disclosed |
| US-6589954-B1 | Indoles, benzimidazoles and benztriazoles which are substituted at the 5 or 6 position with a substituent comprising an aromatic moiety linked through a piperazine ring to said indole, benzimidazole or benztriazole are useful | SCIOS, INC. | 2003-07-08 | — | — | US | disclosed |
| US-20030092717-A1 | Inhibitors of p38 kinase | SCIOS, INC. | 2003-05-15 | — | — | US | disclosed |
| WO-2002042292-A2 | INDOL DERIVATIVE AND THEIR USE AS INHIBITORS OF P38 KINASE | SCIOS INC. (US) | 2002-05-30 | — | — | WO | disclosed |
| EP-1178983-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | Scios Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| US-6340685-B1 | ANTIINFLAMMATORY AGENTS | SCIOS, INC. | 2002-01-22 | — | — | US | disclosed |
| CN-1305464-A | Heterocyclic compounds and methods to treat cardiac failure and other disorders | SCIOS INC (US) | 2001-07-25 | — | — | CN | disclosed |
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-2000071535-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE | SCIOS INC. (US) | 2000-11-30 | — | — | WO | disclosed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144520-A1 | Indole-type derivatives as inhibitors of p38 kinase | CNKSR1, MAPK1, CSNK1A1 | ALDH1A1 1880/4885KDM4E 2597/4885HPGD 1430/4885 |
| US-20030092717-A1 | Inhibitors of p38 kinase | MAPK1, CNKSR1, MOK | ALDH1A1 2031/4885KDM4E 3072/4885HPGD 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.