Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.65 |
| ▸ | BLM | P54132 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 1/20 | 0.61 |
| ▸ | SPR | P35270 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498391 | 0.90 | MTNR1A (0.72) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL25842170 | 0.85 | MTNR1A (0.62) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL14390055 | 0.84 | MTNR1A (0.49) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL24460220 | 0.84 | MTNR1A (0.80) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL10289734 | 0.83 | MTNR1A (0.51) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL4488812 | 0.83 | MTNR1A (0.81) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL26451466 | 0.83 | MTNR1A (0.69) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL30630306 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL4490583 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BCYP1A2BLMMEN1 | |
| SCHEMBL27084981 | 0.81 | MTNR1A (0.81) | MTNR1AMTNR1BCYP1A2BLMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612099-B2 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-11-03 | — | — | US | disclosed |
| CN-101321749-A | Novel vinylogous acid derivatives | HOFFMANN LA ROCHE (CH) | 2008-12-10 | — | — | CN | disclosed |
| EP-1957483-A1 | NOVEL VINYLOGOUS ACIDS DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007063010-A1 | NOVEL VINYLOGOUS ACIDS DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070129421-A1 | Vinylogous acid derivatives | HOFFMANN-LA ROCHE INC. | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129421-A1 | Vinylogous acid derivatives | CMA1, TPSG1, TPSAB1 | MTNR1A 454/4885MTNR1B 756/4885CYP1A2 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.