Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGAV | P06756 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4514765 | 0.87 | KDM4E (0.53) | KDM4EPKMPRMT5GRIN2BPARP1 | |
| SCHEMBL8354967 | 0.85 | BACE1 (0.53) | PRMT5TBK1TGFBR1CHEK2 | |
| SCHEMBL3875180 | 0.84 | ALDH1A1 (0.52) | BCHEPRMT5PDE10APARP1SMN1; SMN2 | |
| SCHEMBL5897564 | 0.84 | HTR2B (0.53) | GRIN2BSMN1; SMN2ITGB3ITGAVITGA2B | |
| SCHEMBL4495617 | 0.84 | PARP1 (0.56) | KDM4EPKMPRMT5PARP1TGFBR1 | |
| SCHEMBL4503780 | 0.83 | PARP1 (0.56) | KDM4EPKMPRMT5PARP1TGFBR1 | |
| SCHEMBL4496634 | 0.82 | MAPT (0.47) | KDM4EPKMPRMT5TBK1BRD4 | |
| SCHEMBL4496187 | 0.82 | PARP1 (0.49) | KDM4EPKMPRMT5PARP1TGFBR1 | |
| SCHEMBL4495524 | 0.80 | PARP1 (0.51) | KDM4EPKMPRMT5PARP1TGFBR1 | |
| SCHEMBL4495515 | 0.79 | PARP1 (0.55) | KDM4EPKMPRMT5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517875-B2 | Piperidine derivatives having CCR3 antagonism | TEIJIN LIMITED (JP) | 2009-04-14 | — | — | US | disclosed |
| US-20080221082-A1 | Ligands of Integrin Receptors | ABBOTT GMBH & CO. KG (DE) | 2008-09-11 | — | — | US | disclosed |
| US-20070032525-A1 | Piperidine derivatives having ccr3 antagonism | TEIJIN LIMITED, A JAPANESE BODY CORPORATE (JP) | 2007-02-08 | — | — | US | disclosed |
| US-7105508-B1 | Integrin receptors antagonists | ABBOTT GMBH & CO. KG (DE) | 2006-09-12 | — | — | US | disclosed |
| EP-1502916-A1 | PIPERIDINE DERIVATIVES HAVING CCR3 ANTAGONISM | TEIJIN LIMITED (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-20040259864-A1 | Substituted pyrimidinone derivatives as ligands of integrin receptors | ABBOTT GMBH & CO. KG (DE) | 2004-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259864-A1 | Substituted pyrimidinone derivatives as ligands of integrin receptors | ITGB3, ITGA5, ITGB5 | KDM4E 3060/4885PKM 3799/4885BCHE 4800/4885 |
| US-20070032525-A1 | Piperidine derivatives having ccr3 antagonism | CCR3, CCR1, CCR4 | KDM4E 3395/4885PKM 3885/4885BCHE 3739/4885 |
| US-20080221082-A1 | Ligands of Integrin Receptors | ITGB3, ITGAV, ITGA2B | KDM4E 4341/4885PKM 4368/4885BCHE 4602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.