⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448231 | 1.00 | ALDH1A1 (0.32) | — | |
| SCHEMBL11715 | 0.97 | — | — | |
| SCHEMBL1448212 | 0.91 | — | — | |
| SCHEMBL1448833 | 0.84 | — | — | |
| SCHEMBL21751012 | 0.78 | HSD17B10 (0.38) | — | |
| SCHEMBL1447629 | 0.78 | ALDH1A1 (0.35) | — | |
| SCHEMBL1448087 | 0.78 | ALDH1A1 (0.35) | — | |
| SCHEMBL6784924 | 0.78 | SIGMAR1 (0.35) | — | |
| SCHEMBL378009 | 0.74 | — | — | |
| SCHEMBL447236 | 0.74 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 711 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3750894-B1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2024-04-03 | — | — | EP | claimed |
| EP-3590941-B1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE-QUINAZOLINE AND -LINKED DIOXANE-QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-11-22 | — | — | EP | claimed |
| EP-3750893-B1 | DIOXAZOLINE COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-04-19 | — | — | EP | claimed |
| WO-2022256299-A1 | 7-MORPHOLINO-5-(3-PHENYL-1 H-PYRAZOL-1 -YL)-FURO[3,2-B]PYRIDINE DERIVATIVES AND SIMILAR COMPOUNDS AS PIKFYVE KINASE INHIBITORS FOR THE TREATMENT OF E.G. AMYOTROPHIC LATERAL SCLEROSIS (ALS) | Verge Analytics, Inc. (US) | 2022-12-08 | — | — | WO | claimed |
| CN-114315930-A | Compound or pharmaceutically acceptable salt thereof, pharmaceutical composition and application | 北京东方百奥医药开发有限公司 | 2022-04-12 | — | — | CN | claimed |
| US-11186583-B2 | 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2021-11-30 | — | — | US | claimed |
| EP-3749670-B1 | 5-ALKYLTHIO-7-[(4-ARYLBENZYL)AMINO]-1(2)H-PYRAZOLO[4,3-D]PYRIMIDINES FOR TREATMENT OF LYMPHOMA | UNIV PALACKEHO (CZ) | 2021-10-06 | — | — | EP | claimed |
| CN-112898286-A | Benzothiophene compound or pharmaceutically acceptable salt and isomer thereof, and preparation method, pharmaceutical composition and application thereof | 中国药科大学 | 2021-06-04 | — | — | CN | claimed |
| US-10980809-B2 | Urea-substituted aromatic ring-linked dioxane-quinazoline and -linked dioxane-quinoline compounds, preparation method therefor and use thereof | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2021-04-20 | — | — | US | claimed |
| CN-111788207-B | Dioxane quinoline compound and preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2021-03-23 | — | — | CN | claimed |
| US-4966833-A | USING HETEROCYCLIC NITROGEN CONTAINING COMPOUND | FUJI PHOTO FILM CO., LTD. (JP) | 1990-10-30 | — | — | US | claimed |
| EP-0373549-A2 | Amino acid derivatives with enzyme-inhibiting properties, process to synthetise them, composition containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-06-20 | — | — | EP | claimed |
| EP-0370454-A2 | Renin-inhibiting amino diol derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-05-30 | — | — | EP | claimed |
| US-4912107-A | Pyrrolocarbazole derivatives, compositions containing them, and methods for using them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | claimed |
| EP-0311110-A2 | Direct positive color photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1989-04-12 | — | — | EP | claimed |
| EP-0004863-B1 | COSMETIC AND PHARMACEUTICAL COMPOSITIONS, TENSIOACTIVE CYCLIC POLYETHERS AND METHODS FOR PREPARING THEM | L'OREAL (FR) | 1982-06-16 | — | — | EP | claimed |
| EP-0014928-B1 | PIPERIDINOPROPYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1982-05-05 | — | — | EP | claimed |
| US-4288442-A | Inhibiting adrenergic β-receptors with piperidinopropyl derivatives | BOEHRINGER MANNHEIM GMBH (DE) | 1981-09-08 | — | — | US | claimed |
| US-4104380-A | Dibenzyl glycolic acid derivatives | WARNER-LAMBERT COMPANY (US) | 1978-08-01 | — | — | US | claimed |
| US-4076937-A | Dibenzyl glycolic acid derivatives | WARNER-LAMBERT COMPANY (US) | 1978-02-28 | — | — | US | claimed |