Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20387967 | 0.86 | NPC1 (0.41) | PDE5ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3530865 | 0.85 | SMN1; SMN2 (0.40) | PDE5ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20416633 | 0.85 | BACE1 (0.37) | PDE5ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20387979 | 0.84 | HPGD (0.56) | RAB9AKMT2AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL19477818 | 0.83 | RAB9A (0.54) | PDE5ARAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL20928733 | 0.81 | SMN1; SMN2 (0.46) | PDE5ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20416635 | 0.81 | MEN1 (0.37) | PDE5ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL19477581 | 0.81 | PDE5A (0.42) | PDE5ACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20436541 | 0.81 | BACE1 (0.34) | PDE5ABACE1 | |
| SCHEMBL28521553 | 0.81 | APP (0.40) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | PDE5A 739/4885CHRNB2 3695/4885CHRNB4 3650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.