Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 17/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507542 | 0.88 | VDR (0.62) | VDRHDAC3HDAC6FFAR4 | |
| SCHEMBL2972327 | 0.82 | ESR1 (0.59) | VDRFFAR4ESR1 | |
| SCHEMBL16178251 | 0.81 | HDAC6 (0.59) | VDRHDAC6ESR1 | |
| SCHEMBL20059953 | 0.80 | FFAR4 (0.53) | VDRFFAR4 | |
| SCHEMBL2971918 | 0.80 | VDR (0.52) | VDRFFAR4 | |
| SCHEMBL4507201 | 0.80 | VDR (0.60) | VDRHDAC3HDAC6FFAR4 | |
| SCHEMBL1058851 | 0.80 | VDR (0.48) | VDRFFAR4 | |
| SCHEMBL4494748 | 0.80 | VDR (0.50) | VDRHDAC3HDAC6FFAR4 | |
| SCHEMBL2950747 | 0.79 | MRGPRX4 (0.55) | VDRFFAR4 | |
| SCHEMBL4492255 | 0.79 | VDR (0.55) | VDRHDAC3HDAC6FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595345-B2 | Vitamin D receptor modulators | ELI LILLY AND COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080200552-A1 | Vitamin D Receptor Modulators | ELI LILLY AND COMPANY (IN) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200552-A1 | Vitamin D Receptor Modulators | VDR, CYP2R1, CYP24A1 | VDR 1/4885HDAC3 1756/4885HDAC6 4464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.