Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | VDR | P11473 | 5/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16178212 | 0.86 | RAB9A (0.51) | MAPTTDP1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL3242065 | 0.86 | NPC1 (0.56) | SMN1; SMN2NPC1HPGDRAB9ACYP2C9 | |
| SCHEMBL27910124 | 0.83 | CCR5 (0.42) | MAPTTDP1L3MBTL1MAPK1SMN1; SMN2 | |
| SCHEMBL4507542 | 0.82 | VDR (0.62) | FFAR4MRGPRX4VDR | |
| SCHEMBL17024331 | 0.82 | MRGPRX4 (0.55) | FFAR4MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL2972327 | 0.82 | ESR1 (0.59) | FFAR4MRGPRX4VDR | |
| SCHEMBL2320679 | 0.82 | FFAR4 (0.56) | FFAR4MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL12295554 | 0.81 | MRGPRX4 (0.68) | FFAR4MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL2318476 | 0.81 | FFAR4 (0.53) | FFAR4MRGPRX4MAPTTDP1L3MBTL1 | |
| SCHEMBL3980539 | 0.81 | FFAR4 (0.52) | FFAR4MRGPRX4MAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794556-B1 | BIS-(ARYL/HETEROARYL)-METHYLENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR TREATING CANCER | GLEASON JAMES L (CA) | 2018-04-18 | — | — | EP | disclosed |