Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7901528 | 0.85 | HSD17B10 (0.48) | HSD17B10AKR1C3SRD5A1MAPK1TP53 | |
| SCHEMBL4518789 | 0.84 | HSD17B10 (0.43) | HSD17B10SRD5A1MAPK1TP53PKM | |
| SCHEMBL1675923 | 0.82 | HSD17B10 (0.49) | HSD17B10AKR1C3MAPK1BRD9USP2 | |
| SCHEMBL2760313 | 0.81 | HSD17B10 (0.57) | HSD17B10AKR1C3TP53BRD9LMNA | |
| SCHEMBL4480763 | 0.81 | SRD5A1 (0.42) | HSD17B10AKR1C3SRD5A1MAPK1TP53 | |
| SCHEMBL19049642 | 0.81 | HSD17B10 (0.43) | HSD17B10SRD5A1TP53USP2LMNA | |
| SCHEMBL30168124 | 0.80 | HSD17B10 (0.59) | HSD17B10AKR1C3MAPK1TP53BRD9 | |
| SCHEMBL3866085 | 0.80 | HSD17B10 (0.59) | HSD17B10AKR1C3MAPK1TP53BRD9 | |
| SCHEMBL8305499 | 0.80 | HSD17B10 (0.51) | HSD17B10AKR1C3TP53BRD9LMNA | |
| SCHEMBL12070446 | 0.80 | HSD17B10 (0.55) | HSD17B10AKR1C3MAPK1TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | HSD17B10 1064/4885AKR1C3 1038/4885SRD5A1 3176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.