SCHEMBL450895

SCHEMBL450895

Clc1[c]n(Br)c2ccccc12

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.34
CYP1A2 P05177 2/20 0.33
CYP2C19 P33261 1/20 0.33
CYP2A6 P11509 1/20 0.33
CYP19A1 P11511 1/20 0.33
KDM4E B2RXH2 1/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6160593 0.76 GPR3 (0.36) GPR3CYP1A2CYP2C19CYP2A6CYP19A1
SCHEMBL938097 0.74 GPR3 (0.44) GPR3CYP1A2CYP2C19CYP2A6CYP19A1
SCHEMBL7647965 0.63 GPR3 (0.52) GPR3CYP1A2CYP2C19CYP19A1KDM4E
SCHEMBL7459883 0.61 GPR3 (0.34) GPR3CYP1A2CYP2C19CYP19A1KDM4E
SCHEMBL2344955 0.60 KDM4E (0.38) GPR3CYP2C19KDM4E
SCHEMBL6894881 0.59 GPR3 (0.37) GPR3CYP1A2CYP2C19CYP19A1KDM4E
SCHEMBL2790587 0.58 SLC6A2 (0.43) GPR3CYP1A2KDM4E
SCHEMBL4000759 0.57 GPR3 (0.46) GPR3CYP1A2CYP2C19CYP19A1KDM4E
SCHEMBL3466198 0.57 GPR3 (0.46) GPR3CYP1A2CYP2C19CYP19A1KDM4E
SCHEMBL7648214 0.57 GPR3 (0.52) GPR3CYP1A2CYP2C19CYP2A6CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 307 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1326653-B1 DETECTION OF THE PRESENCE OF A MICROBE OR RELATED SUBSTANCE AT A LOCATION CAMBRIDGE MEDITECH LTD (GB) 2007-07-11 EP claimed
US-12006368-B2 Anti-frizzled antibodies and methods of use Surrozen Operating, Inc. (US) 2024-06-11 US disclosed
US-20240158523-A1 ANTI-CD40 ANTIBODIES AND METHODS OF USE APEXIGEN, INC. 2024-05-16 US disclosed
US-11982678-B2 Ensemble-decision aliquot ranking UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2024-05-14 US disclosed
US-20240150431-A1 MHC Multimers, Methods for Their Generation, Labeling and Use DAKO DENMARK APS (DK) 2024-05-09 US disclosed
US-20240150458-A1 ANTI-LRP5/6 ANTIBODIES AND METHODS OF USE Surrozen Operating, Inc. (US) 2024-05-09 US disclosed
US-20240141049-A1 WNT SURROGATE MOLECULES AND USES THEREOF Surrozen Operating, Inc. 2024-05-02 US disclosed
US-20240067746-A1 THERAPEUTIC ANTIBODIES GLYCONEX INC (TW) 2024-02-29 US disclosed
CN-117561078-A Biomarkers for assessing risk of developing acute covd-19 and post-acute covd-19 奥默罗斯公司 2024-02-13 CN disclosed
US-20230406948-A1 ANTI-CD40 ANTIBODIES AND METHODS OF USE APEXIGEN, INC. 2023-12-21 US disclosed
EP-0720744-A1 AN ASSAY DEVICE La Mina, Inc. (US) 1996-07-10 EP disclosed
US-5459040-A Enzyme amplified, complex linked, competitive and non-competitive assays for the detection of metal ions THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-10-17 US disclosed
WO-1995026201-A1 BREVICAN, A GLIAL CELL PROTEOGLYCAN LA JOLLA CANCER RESEARCH FOUNDATION (US) 1995-10-05 WO disclosed
WO-1995016207-A1 ASSAY DEVICE WITH A BARRIER FOR REGULATING REAGENT APPLICATION SMITHKLINE DIAGNOSTICS, INC. (US) 1995-06-15 WO disclosed
WO-1995014926-A1 ENZYME AMPLIFIED COMPETITIVE AND SANDWICH CHELATION ASSAYS FOR METAL IONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-06-01 WO disclosed
WO-1995008117-A1 AN ASSAY DEVICE GUIRGUIS RAOUF A (US) 1995-03-23 WO disclosed
EP-0643834-A1 SIMULTANEOUS DRUG TESTING AND FINGERPRINTING ASSAY LA MINA LTD. (US) 1995-03-22 EP disclosed
WO-1994017211-A1 NON-RADIOACTIVE METHOD FOR DETECTING A LABELLED SEGMENT AND A SOLUTION OR COMPOSITION THEREFOR WRIGHT DENNIS (US) 1994-08-04 WO disclosed
WO-1993006486-A1 SIMULTANEOUS DRUG TESTING AND FINGERPRINTING ASSAY LA MINA, LTD. (US) 1993-04-01 WO disclosed
US-4687732-A COUPLING OF MINUTE QUANITY OF SAMPLE WITH DETECTING AGENT YALE UNIVERSITY (US) 1987-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240150431-A1 MHC Multimers, Methods for Their Generation, Labeling and Use MICA, CD74, HLA-DRB1 GPR3 4367/4885CYP1A2 4346/4885CYP2C19 4776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.