Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216078 | 0.85 | KDM4E (0.42) | KDM4EHTTTDP1KMT2AGSK3B | |
| SCHEMBL2214872 | 0.84 | TDP1 (0.40) | KDM4EHTTTDP1KMT2AMAPT | |
| SCHEMBL4508573 | 0.81 | KDM4E (0.42) | KDM4EHTTTDP1PDE3BPDE3A | |
| SCHEMBL4508054 | 0.81 | KDM4E (0.47) | KDM4EHTTTDP1KMT2APDE3B | |
| SCHEMBL2215615 | 0.79 | TDP1 (0.42) | KDM4EHTTTDP1KMT2AGSK3B | |
| SCHEMBL2213684 | 0.78 | CYP2A6 (0.42) | KDM4EHTTTDP1KMT2AGSK3B | |
| SCHEMBL2215831 | 0.78 | KDM4E (0.40) | KDM4EHTTTDP1KMT2APDE3B | |
| SCHEMBL28191915 | 0.77 | TDP1 (0.46) | KDM4EHTTTDP1MAPTRAB9A | |
| SCHEMBL4515404 | 0.77 | LRRK2 (0.45) | KDM4EHTTTDP1KMT2APDE3B | |
| SCHEMBL2213687 | 0.76 | MAPT (0.39) | KDM4EHTTTDP1KMT2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620439-A1 | 8-pyrazinyl-S-spiropyrimidinetrione-oxazinoquinoline derivatives as antibacterial agents | PAH USA 15 LLC (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20090275536-A1 | Antibacterial Agents | PFIZER INC | 2009-11-05 | — | — | US | disclosed |
| US-7557100-B2 | Antibacterial agents | PFIZER INC. (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1971612-A1 | 8-PYRAZINYL-S-SPIROPYRIMIDINETRIONE-OXAZINOQUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | Pfizer Products Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| US-20070197518-A1 | Antibacterial agents | WARNER LAMBERT COMPANY LLC | 2007-08-23 | — | — | US | disclosed |
| WO-2007072151-A1 | 8-PYRAZINYL-S-SPIROPYRIMIDINETRIONE-OXAZINOQUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275536-A1 | Antibacterial Agents | CLPP, MRPL21, SPOUT1 | KDM4E 4288/4885HTT 3802/4885TDP1 3679/4885 |
| US-20070197518-A1 | Antibacterial agents | CLPP, MRPL21, SPOUT1 | KDM4E 4288/4885HTT 3802/4885TDP1 3679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.