Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213873 | 0.83 | LRRK2 (0.40) | LRRK2TSHRNPSR1KDM4EHTT | |
| SCHEMBL2215943 | 0.83 | KDM4E (0.39) | LRRK2TSHRNPSR1KDM4EHTT | |
| SCHEMBL4509999 | 0.77 | KDM4E (0.41) | LRRK2KDM4EHTTPDE3BPDE3A | |
| SCHEMBL2215831 | 0.71 | KDM4E (0.40) | LRRK2TSHRNPSR1KDM4EHTT | |
| SCHEMBL12703547 | 0.71 | ALDH1A1 (0.45) | TSHRNPSR1KDM4EHTTPDE3B | |
| SCHEMBL12703984 | 0.70 | TP53 (0.48) | TSHRNPSR1KDM4EPDE3BPDE3A | |
| SCHEMBL2211823 | 0.70 | TSHR (0.42) | LRRK2TSHRNPSR1KDM4EHTT | |
| SCHEMBL1591119 | 0.70 | KDM4E (0.44) | TSHRNPSR1KDM4EHTTPDE3B | |
| SCHEMBL1591596 | 0.70 | KDM4E (0.44) | TSHRNPSR1KDM4EHTTPDE3B | |
| SCHEMBL13268622 | 0.70 | ALDH1A1 (0.42) | TSHRNPSR1KDM4EHTTPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620439-A1 | 8-pyrazinyl-S-spiropyrimidinetrione-oxazinoquinoline derivatives as antibacterial agents | PAH USA 15 LLC (US) | 2013-07-31 | — | — | EP | disclosed |
| US-20090275536-A1 | Antibacterial Agents | PFIZER INC | 2009-11-05 | — | — | US | disclosed |
| US-7557100-B2 | Antibacterial agents | PFIZER INC. (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1971612-A1 | 8-PYRAZINYL-S-SPIROPYRIMIDINETRIONE-OXAZINOQUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | Pfizer Products Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| US-20070197518-A1 | Antibacterial agents | WARNER LAMBERT COMPANY LLC | 2007-08-23 | — | — | US | disclosed |
| WO-2007072151-A1 | 8-PYRAZINYL-S-SPIROPYRIMIDINETRIONE-OXAZINOQUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275536-A1 | Antibacterial Agents | CLPP, MRPL21, SPOUT1 | LRRK2 2800/4885TSHR 4760/4885NPSR1 4483/4885 |
| US-20070197518-A1 | Antibacterial agents | CLPP, MRPL21, SPOUT1 | LRRK2 2800/4885TSHR 4760/4885NPSR1 4483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.