Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 2/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL29145816 | 0.89 | CYP11B1 (0.52) | HTR5AAHRPDK2PDE3BPDE3A | |
| Isoxazole SCHEMBL2309527 | 0.83 | CYP11B1 (0.42) | HTR5AAHRPDK2PDE3BPDE3A | |
| SCHEMBL8872856 | 0.81 | CA12 (0.55) | HTR5AAHRPDK2NPC1MAPK13 | |
| SCHEMBL1196991 | 0.79 | NPC1 (0.57) | HTR5AAHRPDK2PDE3BPDE3A | |
| SCHEMBL29546699 | 0.79 | CA12 (0.44) | HTR5AAHRPDK2PDE3BPDE3A | |
| SCHEMBL5464714 | 0.79 | AHR (0.48) | HTR5AAHRPDK2NPC1MAPK13 | |
| SCHEMBL14061414 | 0.79 | CA12 (0.56) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL8126700 | 0.77 | AHR (0.72) | AHRPDK2PDE3BPDE3ANPC1 | |
| SCHEMBL310398 | 0.77 | HTR5A (0.57) | HTR5AAHRPDK2NPC1MAPK13 | |
| SCHEMBL6469101 | 0.77 | NPC1 (0.72) | HTR5AAHRPDK2NPC1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1279 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118420550-B | N-hydroxyamide compound containing dihydroquinazolinone, and preparation method and application thereof | 亳州学院 | 2026-05-22 | — | — | CN | claimed |
| EP-3768675-B1 | NOVEL TRIAZOLONE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | YUHAN CORP (KR) | 2026-04-01 | — | — | EP | claimed |
| US-12558357-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | MERCK SHARP & DOHME LLC (US) | 2026-02-24 | — | — | US | claimed |
| US-12492183-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | MERCK SHARP & DOHME LLC (US) | 2025-12-09 | — | — | US | claimed |
| EP-4638538-A1 | LIQUID RHEOLOGY CONTROL AGENT | BYK-Chemie GmbH (DE) | 2025-10-29 | — | — | EP | claimed |
| US-20250302831-A1 | THERAPY FOR ALCOHOL-RELATED LIVER DISEASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, OFFICE OF THE GENERAL COUNSEL (024) | 2025-10-02 | — | — | US | claimed |
| CN-120078781-A | Application of BET/AKT double-pathway active dihydroquinazolinone compound in preparation of anti-prostate cancer drugs | 烟台大学 | 2025-06-03 | — | — | CN | claimed |
| CN-120058710-A | Dihydroquinazolinone compounds and methods of making the same | 烟台大学 | 2025-05-30 | — | — | CN | claimed |
| CN-119306689-A | Method for synthesizing olefin and fluoroolefin | 滁州学院 | 2025-01-14 | — | — | CN | claimed |
| EP-4204413-B1 | DIHYDROQUINAZOLIN-2-ONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS USEFUL IN THE TREATMENT OF HIV | MERCK SHARP & DOHME LLC (US) | 2024-09-25 | — | — | EP | claimed |
| WO-1998027975-A1 | POLY(ADP-RIBOSE) POLYMERASE INHIBITORS TO TREAT DISEASES ASSOCIATED WITH CELLULAR SENESCENCE | GERON CORPORATION (US) | 1998-07-02 | — | — | WO | claimed |
| US-5521315-A | Olefin substituted long chain compounds | CELL THERAPEUTICS, INC. (US) | 1996-05-28 | — | — | US | claimed |
| EP-0677516-A1 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1995-10-18 | — | — | EP | claimed |
| EP-0638309-A1 | Substances inhibiting proteic adp ribosilation suitable to prevent the diabetes mellitus complications | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. (IT) | 1995-02-15 | — | — | EP | claimed |
| EP-0468187-A2 | Cyclic amide derivatives | Eisai Co., Ltd. (JP) | 1992-01-29 | — | — | EP | claimed |
| EP-0316630-A1 | Novel fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | claimed |
| EP-0076199-B1 | TRIAZOLOQUINAZOLONES AND THEIR SALTS, PROCESS AND INTERMEDIATES FOR PREPARING THEM, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1986-12-30 | — | — | EP | claimed |
| US-4202974-A | Process for preparing 3,4-dihydro-2(1H)-quinazolinone derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1980-05-13 | — | — | US | claimed |
| US-4099002-A | QUINAZOLINONE DERIVATIVES AND A PROCESS FOR PRODUCTION THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1978-07-04 | — | — | US | claimed |
| US-4048168-A | Process for preparing 1-polyhaloalkyl-3,4-dihydro-2-(1H)-quinazolinones | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-09-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492183-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | ACIN1, CD4, NFATC1 | HTR5A 3791/4885AHR 3277/4885PDK2 2161/4885 |
| US-20250302831-A1 | THERAPY FOR ALCOHOL-RELATED LIVER DISEASE | CHRNA4, CHRNB4, CHRNA1 | HTR5A 1656/4885AHR 2652/4885PDK2 1813/4885 |
| US-12558357-B2 | Tetrahydroquinazoline derivatives as selective cytotoxic agents | ACIN1, CD4, CCR8 | HTR5A 3937/4885AHR 1988/4885PDK2 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.