SCHEMBL4511366

SCHEMBL4511366

NC(=O)c1ccnc2c(Cl)cccc12

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.69
KDM4E B2RXH2 3/20 0.69
NR4A2 P43354 1/20 0.57
SLC40A1 Q9NP59 2/20 0.52
HAVCR2 Q8TDQ0 1/20 0.51
PIK3R2 O00459 7/20 0.50
KMT2A Q03164 1/20 0.50
ATM Q13315 1/20 0.50
KDM4A O75164 1/20 0.49
RAB9A P51151 1/20 0.49
EGLN1 Q9GZT9 1/20 0.49
HIF1AN Q9NWT6 1/20 0.49
PARP1 P09874 1/20 0.47
PSMD14 O00487 1/20 0.46
NPSR1 Q6W5P4 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
AURKA O14965 1/20 0.43
RPS6KB1 P23443 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15129840 0.85 KDM4E (0.68) L3MBTL1KDM4ENR4A2HAVCR2PIK3R2
SCHEMBL11159839 0.81 KDM4E (1.00) L3MBTL1KDM4ESLC40A1KDM4ARAB9A
SCHEMBL13977533 0.80 KDM4E (0.69) L3MBTL1KDM4ESLC40A1KMT2AATM
SCHEMBL7689718 0.80 PARP1 (0.56) L3MBTL1KDM4ENR4A2KMT2AATM
SCHEMBL19642938 0.80 PSMD14 (0.68) L3MBTL1KDM4ENR4A2SLC40A1HAVCR2
SCHEMBL28184563 0.76 KDM4E (0.68) L3MBTL1KDM4ESLC40A1KDM4ARAB9A
SCHEMBL20415194 0.74 KDM4E (0.60) L3MBTL1KDM4ESLC40A1KMT2AKDM4A
SCHEMBL29410781 0.74 NR4A2 (0.68) L3MBTL1KDM4ENR4A2SLC40A1HAVCR2
SCHEMBL318769 0.74 NR4A2 (0.68) L3MBTL1KDM4ENR4A2SLC40A1HAVCR2
SCHEMBL11163301 0.73 KDM4E (0.44) L3MBTL1KDM4EKMT2AATMRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090029855-A1 Quinoline Derivatives and Their Use as Pesticides BASF SE (DE) 2009-01-29 US disclosed
EP-2007727-A1 QUINOLINE DERIVATIVES AND THEIR USE AS PESTICIDES BASF SE (DE) 2008-12-31 EP disclosed
WO-2007104726-A1 QUINOLINE DERIVATIVES AND THEIR USE AS PESTICIDES BASF SE (DE) 2007-09-20 WO disclosed
US-4396620-A BACTERICIDES ELI LILLY AND COMPANY (US) 1983-08-02 US disclosed
US-4382931-A 3'-Substituted quinolinium cephalosporins ELI LILLY AND COMPANY (US) 1983-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090029855-A1 Quinoline Derivatives and Their Use as Pesticides CBR3, HCRTR1, HCAR3 L3MBTL1 697/4885KDM4E 4207/4885NR4A2 480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.