Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.40 |
| ▸ | KLK1 | P06870 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508090 | 0.93 | MAPK14 (0.50) | MAPK14S1PR1S1PR5KMT2AKLK1 | |
| SCHEMBL4515403 | 0.87 | CD274 (0.42) | MAPK14KMT2ACD274MAPT | |
| SCHEMBL4497552 | 0.86 | MAPK14 (0.46) | MAPK14S1PR1S1PR5CD274PDE1A | |
| SCHEMBL4513845 | 0.86 | MAPK14 (0.46) | MAPK14KMT2AMAPT | |
| SCHEMBL4513949 | 0.86 | MAPK14 (0.50) | MAPK14S1PR1S1PR5KMT2AKLK1 | |
| SCHEMBL4516348 | 0.83 | CD274 (0.43) | S1PR1S1PR5KMT2ACD274PDE1A | |
| SCHEMBL4512169 | 0.83 | MAPK14 (0.52) | MAPK14KLK1MAPTPDE1APDE1B | |
| SCHEMBL4565096 | 0.82 | CD274 (0.45) | MAPK14CD274MAPT | |
| SCHEMBL4504769 | 0.81 | MAPK14 (0.49) | MAPK14KMT2AMAPT | |
| SCHEMBL4515517 | 0.81 | MAPK14 (0.48) | MAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | MAPK14 117/4885S1PR1 1772/4885S1PR5 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.