Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511523 | 0.87 | MAPK14 (0.42) | CD274MAPK14KMT2AMAPT | |
| SCHEMBL4511905 | 0.87 | MAPK14 (0.45) | CD274MAPK14ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4513845 | 0.84 | MAPK14 (0.46) | MAPK14TP53ALDH1A1KDM4ERCE1 | |
| SCHEMBL4513655 | 0.84 | MAPK14 (0.42) | CD274MAPK14KDM4EMAPK1LMNA | |
| SCHEMBL13678626 | 0.81 | MAPK14 (0.40) | CD274MAPK14ALDH1A1KDM4ELMNA | |
| SCHEMBL4508090 | 0.81 | MAPK14 (0.50) | MAPK14POLBKMT2AMAPT | |
| SCHEMBL4565096 | 0.80 | CD274 (0.45) | CD274MAPK14TP53ALDH1A1LMNA | |
| SCHEMBL4499822 | 0.80 | MAPK14 (0.48) | MAPK14 | |
| SCHEMBL4513949 | 0.79 | MAPK14 (0.50) | MAPK14POLBKMT2AMAPT | |
| SCHEMBL4520978 | 0.79 | MAPK14 (0.44) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PFIZER INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270350-A1 | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives | PDXK, UMPS, CDK2 | CD274 2673/4885MAPK14 117/4885TP53 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.