Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Tolperisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.76 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.76 |
| ▸ | DRD3 | P35462 | 2/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolperisone SCHEMBL148499 | 0.87 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL17223884 | 0.87 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL21451092 | 0.87 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL4780118 | 0.87 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL4516510 | 0.87 | CHRM2 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL872770 | 0.86 | ALDH1A1 (1.00) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| SCHEMBL9172663 | 0.86 | CHRM2 (0.97) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL15663055 | 0.85 | CHRM2 (0.94) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL4513224 | 0.80 | CHRM2 (0.74) | CHRM2ADRA2BDRD3SIGMAR1HRH3 | |
| Tolperisone SCHEMBL11664656 | 0.80 | CHRM2 (0.74) | CHRM2ADRA2BDRD3SIGMAR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090298893-A1 | Addition Salts of Tolperisone, Processes for Their Preparation and Use Thereof | BIRDS PHARMA GMBH BEROLINA INNOVATIVE RESEARCH & DEVELOPMENT SERVICES (DE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298893-A1 | Addition Salts of Tolperisone, Processes for Their Preparation and Use Thereof | CYP21A2, PTMS, THOP1 | CHRM2 4063/4885ADRA2B 502/4885DRD3 861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.