Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.36 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4507288 | 0.85 | ALDH1A1 (0.44) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A | |
| SCHEMBL4509405 | 0.74 | CYP1A2 (0.44) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A | |
| SCHEMBL25508 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A | |
| SCHEMBL30879493 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A | |
| SCHEMBL2637178 | 0.71 | GRK6 (0.45) | ALDH1A1HSD17B10CYP1A2HPGDTSHR | |
| SCHEMBL29473502 | 0.71 | GRK6 (0.45) | ALDH1A1HSD17B10CYP1A2HPGDTSHR | |
| Benzene SCHEMBL20788840 | 0.71 | ALDH1A1 (0.48) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A | |
| Carbazole SCHEMBL28802619 | 0.69 | ALDH1A1 (0.45) | ALDH1A1HSD17B10HPGDMAOAACHE | |
| SCHEMBL2321840 | 0.68 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A | |
| SCHEMBL132650 | 0.68 | ALDH1A1 (0.62) | ALDH1A1HSD17B10CYP1A2HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252814-B2 | Agents and crystals for improving excretory potency of urinary bladder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-08-28 | — | — | US | disclosed |
| US-20090264467-A1 | Agents and crystals for improving excretory potency of urinary bladder | ISHIHARA YUJI | 2009-10-22 | — | — | US | disclosed |
| US-7462628-B2 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-12-09 | — | — | US | disclosed |
| EP-1891954-A2 | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder | Takeda Pharmaceutical Company Limited (JP) | 2008-02-27 | — | — | EP | disclosed |
| US-20070232538-A1 | Uses of polypeptides | TAKEDA PHARMACEUTICAL COMPANY, LTD (JP) | 2007-10-04 | — | — | US | disclosed |
| US-20070021391-A1 | Preventive/remedy for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-25 | — | — | US | disclosed |
| US-20060281725-A1 | Agents and crystals for improving excretory potency of urinary bladder | ISIHARA YUJI | 2006-12-14 | — | — | US | disclosed |
| US-7138533-B2 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-11-21 | — | — | US | disclosed |
| US-7132547-B2 | Preventives/remedies for urinary disturbance | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-11-07 | — | — | US | disclosed |
| US-20060211675-A1 | Preventives/remedies for urinary disturbance | ISHIHARA YUJI | 2006-09-21 | — | — | US | disclosed |
| WO-1996020927-A1 | DIBENZ[cd,f]INDOLE DERIVATIVES | NOVARTIS AG (CH) | 1996-07-11 | — | — | WO | disclosed |
| EP-0655451-A1 | Tetracyclic condensed heterocyclic compounds for the treatment of senile dementia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994025461-A1 | CERTAIN CYCLOALKYL AND AZACYCLOALKYL PYRROLOPYRIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-10 | — | — | WO | disclosed |
| EP-0216072-B1 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1992-08-26 | — | — | EP | disclosed |
| EP-0216072-B1 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1992-08-26 | — | — | EP | disclosed |
| US-4795759-A | PREVENTION ALCOHOLISM | SANDOZ LTD. (CH) | 1989-01-03 | — | — | US | disclosed |
| US-4795759-A | PREVENTION ALCOHOLISM | SANDOZ LTD. (CH) | 1989-01-03 | — | — | US | disclosed |
| EP-0216072-A2 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1987-04-01 | — | — | EP | disclosed |
| EP-0216072-A2 | Use of dibenz[cd,f]indole derivatives in the prevention of alcohol abuse | SANDOZ AG (CH) | 1987-04-01 | — | — | EP | disclosed |
| US-4602032-A | Dibenz[cd,f]indole derivatives, their preparation and pharmaceutical compositions containing them | SANDOZ LTD. (CH) | 1986-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021391-A1 | Preventive/remedy for urinary disturbance | ACHE, BCHE, CHAT | ALDH1A1 346/4885HSD17B10 826/4885CYP1A2 725/4885 |
| US-20090264467-A1 | Agents and crystals for improving excretory potency of urinary bladder | ACHE, BCHE, PDE7A | ALDH1A1 1143/4885HSD17B10 3565/4885CYP1A2 1169/4885 |
| US-20070232538-A1 | Uses of polypeptides | NPSR1, SCTR, GRPR | ALDH1A1 3946/4885HSD17B10 4390/4885CYP1A2 4859/4885 |
| US-20060281725-A1 | Agents and crystals for improving excretory potency of urinary bladder | ACHE, BCHE, PDE7A | ALDH1A1 1245/4885HSD17B10 3568/4885CYP1A2 1276/4885 |
| US-20060211675-A1 | Preventives/remedies for urinary disturbance | ACHE, BPHL, ACE | ALDH1A1 212/4885HSD17B10 1291/4885CYP1A2 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.