SCHEMBL4515449

SCHEMBL4515449

O=[N+]([O-])/C=C/c1ccc(-c2ccc(F)cc2)cc1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 5/20 0.54
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
VCP P55072 2/20 0.43
ALDH1A1 P00352 2/20 0.43
HSP90AA1 P07900 2/20 0.43
MAPT P10636 2/20 0.43
HTT P42858 2/20 0.43
LMNA P02545 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
NFE2L2 Q16236 2/20 0.42
TLR4 O00206 2/20 0.40
TLR2 O60603 2/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
PSMD14 O00487 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
RXRA P19793 1/20 0.38
PRMT1 Q99873 1/20 0.38
MITF O75030 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4515454 1.00 FBP1 (0.54) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL4515451 1.00 FBP1 (0.54) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL121050 0.86 FBP1 (0.56) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL147060 0.86 FBP1 (0.56) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL4043370 0.77 VCP (0.53) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL29149940 0.77 FBP1 (0.53) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL18590413 0.77 FBP1 (0.58) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL12860019 0.77 VCP (0.53) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL20177880 0.77 FBP1 (0.53) FBP1KMT2AMEN1VCPALDH1A1
SCHEMBL30259520 0.77 FBP1 (0.53) FBP1KMT2AMEN1VCPALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7632850-B2 2-amino-2-oxoethyl 1-(4'-fluoro-1,1'-biphenyl-4-yl)cyclopropylmethylcarbamate and 2-(methylamino)-2-oxoethyl 1-(4'-fluoro-1,1'-biphenyl-4-yl)cyclopropylmethylcarbamate; fatty acid amide (FAAH) hyrdrolase inhibitors; analgesics; neuropathic pain;psychological disorders; anticarcinogenic agents; AIDS SANOFI-AVENTIS (FR) 2009-12-15 US disclosed
US-20060014830-A1 Arylalkylcarbamate derivatives production and use thereof in therapy SANOFI-AVENTIS (FR) 2006-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014830-A1 Arylalkylcarbamate derivatives production and use thereof in therapy CBR3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C5 FBP1 1712/4885KMT2A 4138/4885MEN1 1295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.