Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4525396 | 0.98 | ALDH1A1 (0.43) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL4516113 | 0.87 | CYP1A2 (0.42) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL4525399 | 0.85 | ALDH1A1 (0.42) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL30354180 | 0.80 | ALDH1A1 (0.42) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL16592455 | 0.78 | THRB (0.42) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL1262968 | 0.77 | LMNA (0.40) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL14948194 | 0.75 | CHRM5 (0.36) | LMNACYP2D6MAPK1GAACYP2C19 | |
| SCHEMBL9182298 | 0.75 | CHRNB4 (0.48) | LMNACYP2D6CYP3A4MAPK1THPO | |
| Acetylcholine SCHEMBL14840380 | 0.75 | CHRM1 (0.58) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 | |
| SCHEMBL11725693 | 0.74 | LMNA (0.50) | ALDH1A1LMNACYP2D6CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099044-A1 | Nanoparticles and Method to Control Nanoparticle Spacing | OREGON, UNIVERSITY OF | 2009-04-16 | — | — | US | disclosed |
| WO-2006127675-A2 | NANOPARTICLES AND METHOD TO CONTROL NANOPARTICLE SPACING | STATE OF OREGON ACTING BY & THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099044-A1 | Nanoparticles and Method to Control Nanoparticle Spacing | ICAM1, L1CAM, EPCAM | ALDH1A1 271/4885LMNA 4647/4885CYP2D6 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.