Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255039 | 0.82 | KMT2A (0.64) | ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL3255043 | 0.82 | KMT2A (0.64) | ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL13848573 | 0.82 | KMT2A (0.64) | ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL5009753 | 0.81 | KMT2A (0.49) | CA1CA2ALDH1A1L3MBTL1GAA | |
| SCHEMBL3578941 | 0.81 | ESR1 (0.54) | CA1CA2ALDH1A1GAAKMT2A | |
| SCHEMBL13014942 | 0.79 | HPGD (0.56) | CA1CA2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL4511382 | 0.79 | CA1 (0.48) | CA1CA2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1154849 | 0.79 | L3MBTL1 (0.49) | ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL17309222 | 0.79 | RAB9A (0.49) | CA1CA2KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2390293 | 0.79 | SLC6A3 (0.46) | ALDH1A1L3MBTL1GAAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062297-A1 | Hydroxyalkylarylamide Derivatives | MERCK SHARP & DOHME CORP. | 2009-03-05 | — | — | US | disclosed |
| EP-1973405-A2 | HYDROXYALKYLARYLAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007087130-A2 | HYDROXYALKYLARYLAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062297-A1 | Hydroxyalkylarylamide Derivatives | AADAC, HDAC5, HDAC3 | CA1 963/4885CA2 1202/4885ALDH1A1 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.