SCHEMBL4516363

SCHEMBL4516363

C[Si](O)(O)c1ccc(N)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.44
MAPT P10636 2/20 0.44
KMT2A Q03164 2/20 0.44
ALDH1A1 P00352 8/20 0.41
CYP3A4 P08684 6/20 0.41
ALOX15 P16050 3/20 0.41
ACHE P22303 2/20 0.41
CA3 P07451 1/20 0.41
THRB P10828 1/20 0.41
CA6 P23280 1/20 0.41
CASP1 P29466 1/20 0.41
HIF1A Q16665 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CA14 Q9ULX7 1/20 0.41
TDP1 Q9NUW8 6/20 0.39
TSHR P16473 3/20 0.39
TP53 P04637 2/20 0.38
CYP19A1 P11511 2/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4527473 0.93 ALDH1A1 (0.52) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL272363 0.85 ESR1 (0.38)
SCHEMBL9326306 0.83 MEN1 (0.44) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL27043326 0.77 ALDH1A1 (0.52) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL4511521 0.77 MAPT (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL6433024 0.77 ESR1 (0.35)
SCHEMBL3923695 0.77 MEN1 (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL65963 0.77 MEN1 (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL22694323 0.77 MEN1 (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL1172568 0.77 MEN1 (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7507480-B2 Corrosion-resistant metal surfaces BROOKHAVEN SCIENCE ASSOCIATES, LLC (US) 2009-03-24 US disclosed
US-20060269760-A1 Corrosion-resistant metal surfaces ENERGY, UNITED STATES DEPARTMENT OF 2006-11-30 US disclosed