SCHEMBL9326306

SCHEMBL9326306

C[Si](C)(O)c1ccc(N)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.44
MAPT P10636 3/20 0.44
KMT2A Q03164 3/20 0.44
ALDH1A1 P00352 7/20 0.41
CYP3A4 P08684 4/20 0.41
ALOX15 P16050 3/20 0.41
HSD17B10 Q99714 2/20 0.41
ACHE P22303 2/20 0.41
CA3 P07451 1/20 0.41
THRB P10828 1/20 0.41
CA6 P23280 1/20 0.41
CASP1 P29466 1/20 0.41
HIF1A Q16665 1/20 0.41
CA14 Q9ULX7 1/20 0.41
TDP1 Q9NUW8 4/20 0.38
TP53 P04637 3/20 0.38
NR1I2 O75469 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
CYP19A1 P11511 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27043326 0.93 ALDH1A1 (0.52) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL27043327 0.87 APP (0.54) MEN1MAPTKMT2ANPC1RAB9A
SCHEMBL235602 0.85 NR1I2 (0.43) NR1I2HPGD
SCHEMBL4516363 0.83 MEN1 (0.44) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL27043325 0.83 APP (0.48) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL7902561 0.82 NR1I2 (0.42) NR1I2HPGD
SCHEMBL4527473 0.77 ALDH1A1 (0.52) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL65963 0.77 MEN1 (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4
SCHEMBL29086820 0.77 NR1I2 (0.39) NR1I2HPGD
SCHEMBL1172568 0.77 MEN1 (0.50) MEN1MAPTKMT2AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210017420-A1 STRUCTURE BODY, SENSOR, AND METHOD FOR PRODUCING STRUCTURE BODY DENSO CORPORATION (JP) 2021-01-21 US claimed
WO-2019193943-A1 STRUCTURE BODY, SENSOR, AND STRUCTURE BODY PRODUCTION METHOD 株式会社デンソー 2019-10-10 WO claimed
US-11485877-B2 Structure body, sensor, and method for producing structure body DENSO CORPORATION (JP) 2022-11-01 US disclosed
US-20210017420-A1 STRUCTURE BODY, SENSOR, AND METHOD FOR PRODUCING STRUCTURE BODY DENSO CORPORATION (JP) 2021-01-21 US disclosed
US-20210017420-A1 STRUCTURE BODY, SENSOR, AND METHOD FOR PRODUCING STRUCTURE BODY DENSO CORPORATION (JP) 2021-01-21 US disclosed
US-10723845-B2 Process for preparing linear carbosiloxane polymers DOW SILICONES CORPORATION (US) 2020-07-28 US disclosed
US-20200079911-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING EUROPE S.A. 2020-03-12 US disclosed
EP-3153540-B1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING (US) 2018-06-06 EP disclosed
WO-2017062091-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS DOW CORNING CORPORATION (US) 2017-04-13 WO disclosed
EP-3153540-A1 PROCESS FOR PREPARING LINEAR CARBOSILOXANE POLYMERS Dow Corning Corporation (US) 2017-04-12 EP disclosed
WO-2015106292-A1 BCR-ABL TYROSINE-KINASE LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2015-07-16 WO disclosed
US-20140243286-A1 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2014-08-28 US disclosed
US-20140243286-A1 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME COFERON, INC. (US) 2014-08-28 US disclosed
US-5286890-A Aromatic amine terminated silicone monomers, oligomers, and polymers therefrom HUGHES AIRCRAFT COMPANY (US) 1994-02-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243286-A1 BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME BRDT, BRD4, BRD1 MEN1 836/4885MAPT 1845/4885KMT2A 2014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.