Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 9/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14663431 | 0.88 | CYP2D6 (0.50) | CYP2D6TSHRCHRM2CHRM3CYP3A4 | |
| SCHEMBL12910564 | 0.87 | CYP2D6 (0.55) | CYP2D6TSHRCYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL8248950 | 0.82 | NPFFR1 (0.48) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL25248772 | 0.82 | CYP2D6 (0.50) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL7007725 | 0.76 | OPRL1 (0.53) | CYP2D6TSHROPRL1CYP3A4ALDH1A1 | |
| SCHEMBL16431003 | 0.74 | CYP2D6 (0.78) | CYP2D6TSHRCHRM2CHRM3CYP3A4 | |
| SCHEMBL19586554 | 0.73 | EPHX2 (0.49) | CYP2D6TSHRCHRM2CHRM3CYP3A4 | |
| SCHEMBL484761 | 0.73 | NPFFR1 (0.53) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL1147211 | 0.73 | OPRL1 (0.63) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL30893978 | 0.73 | HCRTR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176789-A1 | Diazaspirodecane orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176789-A1 | Diazaspirodecane orexin receptor antagonists | HCRTR2, HCRTR1, OXTR | CYP2D6 3168/4885TSHR 297/4885OPRL1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.