Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.53 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2524338 | 0.94 | CYP2D6 (0.57) | NPFFR1NPFFR2CYP2D6TSHROPRL1 | |
| Hydrochloric Acid SCHEMBL4481783 | 0.92 | POLB (0.58) | NPFFR1NPFFR2CYP2D6TSHROPRL1 | |
| SCHEMBL3318898 | 0.84 | OPRL1 (0.54) | NPFFR1NPFFR2CYP2D6TSHROPRL1 | |
| SCHEMBL485328 | 0.83 | SIGMAR1 (0.55) | NPFFR1NPFFR2CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL14027004 | 0.83 | CYP2D6 (0.50) | NPFFR1NPFFR2CYP2D6TSHROPRL1 | |
| SCHEMBL484891 | 0.81 | OPRL1 (0.53) | NPFFR1NPFFR2CYP2D6TSHROPRL1 | |
| SCHEMBL4023771 | 0.80 | OPRL1 (0.59) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL16579978 | 0.79 | CYP2D6 (0.55) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL6783749 | 0.79 | OPRL1 (0.58) | CYP2D6TSHROPRL1CHRM2CHRM3 | |
| SCHEMBL9049592 | 0.78 | CYP2D6 (0.55) | CYP2D6TSHROPRL1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | GRUENENTHAL GMBH (DE) | 2013-09-05 | — | — | US | disclosed |
| US-8455475-B2 | Substituted spiro-amide compounds | GRUENENTHAL GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| EP-2411381-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-02-01 | — | — | EP | disclosed |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | GRUENENTHAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| WO-2010108651-A1 | SUBSTITUTED SPIRO-AMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231327-A1 | Substituted Spiro-Amide Compounds | BDKRB1, BDKRB2, REN | NPFFR1 92/4885NPFFR2 332/4885CYP2D6 1926/4885 |
| US-20100249095-A1 | Substituted Spiro-amide Compounds | BDKRB1, BDKRB2, REN | NPFFR1 92/4885NPFFR2 332/4885CYP2D6 1926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.