Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.42 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.42 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.42 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.42 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.42 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.42 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.42 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2161512 | 0.83 | AKR1C3 (0.59) | KDM2BKDM4CAKR1C3AKR1C2PTGS1 | |
| SCHEMBL1123024 | 0.80 | PTGS2 (0.59) | APPCYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL6272901 | 0.78 | PTGS2 (0.52) | APPCYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL9680432 | 0.78 | PTGS2 (0.50) | APPCYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL9680427 | 0.78 | PTGS2 (0.50) | APPCYP2C19AKR1C3AKR1C2PTGS1 | |
| SCHEMBL7962904 | 0.78 | PTGS1 (0.50) | AKR1C3AKR1C2PTGS1PTGS2CDC42 | |
| SCHEMBL25002931 | 0.75 | SCN10A (0.67) | SCN10AKDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL2863908 | 0.74 | SCN10A (0.51) | SCN10AKDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL6180227 | 0.74 | SCN10A (0.58) | SCN10AKDM5AKDM2BKDM4CKDM5B | |
| SCHEMBL1758489 | 0.74 | SCN10A (0.62) | SCN10AKDM5AKDM2BKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7638629-B2 | Piperidines and related compounds for treatment of alzheimer's disease | Merck Sharp & Dohme Ltd, (GB) | 2009-12-29 | — | — | US | disclosed |
| US-20080021043-A1 | Piperidines and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021043-A1 | Piperidines and Related Compounds for Treatment of Alzheimer's Disease | PSEN1, PSEN2, APP | SCN10A 478/4885KDM5A 3615/4885KDM2B 3357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.