Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.50 |
| ▸ | TRPV2 | Q9Y5S1 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10989218 | 0.91 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11381814 | 0.85 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL4509269 | 0.85 | CNR2 (0.49) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL10367142 | 0.82 | ALDH1A1 (0.63) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL1146705 | 0.79 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL20116002 | 0.78 | ALDH1A1 (0.74) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL10482619 | 0.77 | ALDH1A1 (0.72) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11104746 | 0.76 | PTPN1 (0.57) | ALDH1A1TRPA1CNR1CNR2TRPV1 | |
| SCHEMBL10991078 | 0.75 | CNR2 (0.43) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11112856 | 0.75 | PTPN1 (0.49) | TRPA1CNR1CNR2TRPV1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227511-B2 | Substituted chromanol derivatives and their use | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-07-24 | — | — | US | disclosed |
| US-20090306197-A1 | Substituted Chromanol Derivatives and Their Use | BAYER HEALTHCARE AG (DE) | 2009-12-10 | — | — | US | disclosed |
| EP-1999123-A1 | SUBSTITUTED CHROMANOL DERIVATIVES AND THEIR USE | Bayer HealthCare AG (DE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107243-A1 | SUBSTITUTED CHROMANOL DERIVATIVES AND THEIR USE | BAYER HEALTHCARE AG (DE) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306197-A1 | Substituted Chromanol Derivatives and Their Use | CYP46A1, CBX3, CDYL | ALDH1A1 1180/4885RAB9A 2455/4885NPC1 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.