Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518634 | 0.82 | ALDH1A1 (0.65) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11381814 | 0.79 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL10989218 | 0.79 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL4506446 | 0.79 | ALDH1A1 (0.68) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL1146705 | 0.78 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL10403135 | 0.78 | RAB9A (0.65) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL20116002 | 0.77 | ALDH1A1 (0.74) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL10482619 | 0.76 | ALDH1A1 (0.72) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL10365140 | 0.75 | MAOB (0.54) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11380576 | 0.73 | ALDH1A1 (0.68) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089781-B1 | BICYCLIC BENZO FUSED COMPOUNDS | PFIZER INC. (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4870084-A | ANALGESICS, ANTIDIARRHEALS | PFIZER INC. (US) | 1989-09-26 | — | — | US | disclosed |
| US-4863934-A | Bicyclic benzo fused pyran compounds used for producing analgesia | PFIZER INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4841078-A | ANALGESICS | PFIZER INC. (US) | 1989-06-20 | — | — | US | disclosed |
| US-4680404-A | ANALGESICS, TRANQUILIZERS, ANTIEMETICS, DIURETICS, ANTICONVULSANTS | PFIZER INC. (US) | 1987-07-14 | — | — | US | disclosed |
| US-4486428-A | ANALGESICS, ANTIEMETICS | PFIZER INC. (US) | 1984-12-04 | — | — | US | disclosed |