Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4515642 | 0.90 | KDM4E (0.43) | KDM4EALDH1A1MEN1MAPTHTT | |
| Trifluoroacetic Acid SCHEMBL4527558 | 0.89 | HRH4 (0.42) | TLR9TLR8TLR7KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4529169 | 0.88 | KDM4E (0.41) | KDM4EALDH1A1MEN1MAPTHTT | |
| Trifluoroacetic Acid SCHEMBL4523754 | 0.88 | CNR1 (0.43) | KDM4EALDH1A1MEN1MAPTHTT | |
| Trifluoroacetic Acid SCHEMBL4514539 | 0.88 | ALDH1A1 (0.43) | KDM4EALDH1A1MEN1MAPTHTT | |
| Trifluoroacetic Acid SCHEMBL4520540 | 0.87 | TPSAB1 (0.41) | KDM4EALDH1A1MEN1MAPTHTT | |
| SCHEMBL4524123 | 0.87 | HTR2A (0.48) | KDM4EALDH1A1MEN1MAPTHTT | |
| SCHEMBL4528287 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1MEN1MAPTHTT | |
| Trifluoroacetic Acid SCHEMBL4530227 | 0.86 | CNR1 (0.46) | TLR9TLR8TLR7KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4515923 | 0.86 | MCL1 (0.44) | KDM4EALDH1A1MEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | claimed |
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | BRANE DISCOVERY S.R.L. (IT) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275555-A1 | Substituted indole ligands for the ORL-1 receptor | OGFRL1, OPRL1, ORMDL3 | TLR9 1208/4885TLR8 852/4885TLR7 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.