Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508222 | 0.86 | TRPA1 (0.37) | ALDH1A1MAPTGAASMN1; SMN2TP53 | |
| SCHEMBL9400332 | 0.84 | ALDH1A1 (0.53) | ALDH1A1MAPTGAASMN1; SMN2TP53 | |
| SCHEMBL9970968 | 0.79 | AR (0.45) | ALDH1A1TP53TRPA1METAP2CXCR2 | |
| SCHEMBL14117285 | 0.77 | TRPA1 (0.52) | ALDH1A1TSHRTRPA1MEN1KMT2A | |
| SCHEMBL4518802 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2TSHRMAPK1TRPA1 | |
| SCHEMBL19590684 | 0.77 | HSPA5 (0.39) | ALDH1A1GAASMN1; SMN2TSHRTRPA1 | |
| SCHEMBL16994789 | 0.77 | ALDH1A1 (0.47) | ALDH1A1MAPTGAASMN1; SMN2TP53 | |
| SCHEMBL4475121 | 0.76 | PIK3CA (0.41) | ALDH1A1SMN1; SMN2TRPA1KMT2AL3MBTL1 | |
| SCHEMBL4475971 | 0.76 | ALDH1A1 (0.47) | ALDH1A1MAPTSMN1; SMN2TP53MEN1 | |
| SCHEMBL17774831 | 0.75 | GAA (0.49) | ALDH1A1MAPTGAASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | ALDH1A1 780/4885MAPT 4633/4885GAA 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.