SCHEMBL451966

SCHEMBL451966

C[CH]OC(=O)CCCCC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DGKA P23743 1/20 0.54
TSHR P16473 4/20 0.50
LMNA P02545 2/20 0.50
PAM P19021 2/20 0.48
CES2 O00748 4/20 0.48
CES1 P23141 4/20 0.48
MAPT P10636 2/20 0.47
MAPK1 P28482 1/20 0.47
AKR1B1 P15121 1/20 0.46
PPARG P37231 4/20 0.44
PPARD Q03181 4/20 0.44
PPARA Q07869 4/20 0.44
GPR84 Q9NQS5 3/20 0.44
HDAC11 Q96DB2 3/20 0.44
ALDH1A1 P00352 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
SLC22A6 Q4U2R8 1/20 0.44
SLC22A8 Q8TCC7 1/20 0.44
TLR2 O60603 1/20 0.44
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6163945 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL698428 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL6163541 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL8332466 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL8896528 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL2254535 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL2255805 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL5508667 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL2892144 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2
SCHEMBL5517470 0.98 DGKA (0.57) DGKATSHRLMNAPAMCES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 338 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0643059-A1 3-(3-Pyridinyl)-1H-indoles as thromboxane A2 synthetase inhibitors Pfizer Limited (GB) 1995-03-15 EP claimed
EP-0594588-A1 CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS Pfizer Limited (GB) 1994-05-04 EP claimed
EP-0358398-B1 CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS Pfizer Limited (GB) 1993-03-10 EP claimed
WO-1991013054-A1 CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS PFIZER LIMITED (GB) 1991-09-05 WO claimed
EP-0358398-A1 Cycloalkyl-substituted glutaramide antihypertensive agents Pfizer Limited (GB) 1990-03-14 EP claimed
US-4613614-A Prostaglandin I2 ester and fat emulsion containing the same THE GREEN CROSS CORPORATION (JP) 1986-09-23 US claimed
US-20240131180-A1 DRUG ANTIBODY CONJUGATES PHARMA MAR, S.A. (ES) 2024-04-25 US disclosed
EP-4025253-B1 DRUG ANTIBODY CONJUGATES PHARMA MAR SA (ES) 2024-03-20 EP disclosed
CN-114615999-B Drug antibody conjugates 法马马有限公司 2024-03-08 CN disclosed
US-20230218774-A1 DRUG ANTIBODY CONJUGATES PHARMA MAR, S.A. (ES) 2023-07-13 US disclosed
CN-113316564-B Fused tricyclic deuterated derivative, and composition and application thereof 四川海思科制药有限公司 2023-06-09 CN disclosed
WO-2023063154-A1 TRACER COMPOSITION FOR RADIOACTIVE PET DIAGNOSIS, INTERMEDIATE THEREOF, AND PRODUCTION METHOD THEREOF 国立大学法人大阪大学 2023-04-20 WO disclosed
EP-4138923-A1 DRUG ANTIBODY CONJUGATES Pharma Mar, S.A. (ES) 2023-03-01 EP disclosed
EP-0227640-A1 Polyolefins stabilised by bis-(polyalkylpiperidinyl-amino)-1,3,5-triazines CIBA-GEIGY AG (CH) 1987-07-01 EP disclosed
US-4613614-A Prostaglandin I2 ester and fat emulsion containing the same THE GREEN CROSS CORPORATION (JP) 1986-09-23 US disclosed
US-4605651-A BACTERICIDES KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1986-08-12 US disclosed
EP-0108942-A2 Cephalosporin derivatives, methods of production thereof and prophylactic and therapeutic agents for bacterial infection Kyoto Pharmaceutical Industries, Ltd. (JP) 1984-05-23 EP disclosed
EP-0107615-A1 Polyolefins stabilized by bis or tris (polyalkylpiperidinyl-amino) 1,3,5-triazines CIBA-GEIGY AG (CH) 1984-05-02 EP disclosed
US-4229345-A (2-Chloro-4-cyanophenyl) (4-dialkylaminophenyl)-diazine dye useful for transfer printing BASF AKTIENGESELLSCHAFT (DE) 1980-10-21 US disclosed
US-3994939-A BACTERICIDES PFIZER INC. (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240131180-A1 DRUG ANTIBODY CONJUGATES STT3B, STT3A, TTL DGKA 2103/4885TSHR 1530/4885LMNA 1254/4885
US-20230218774-A1 DRUG ANTIBODY CONJUGATES B3GAT3, MGAT3, SDAD1 DGKA 2469/4885TSHR 1572/4885LMNA 3861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.