Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526744 | 0.91 | CYP2D6 (0.43) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4527417 | 0.88 | CYP2D6 (0.46) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4532216 | 0.86 | CYP2D6 (0.45) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4527746 | 0.84 | CYP2D6 (0.39) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4528733 | 0.83 | CYP2D6 (0.39) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4533000 | 0.78 | CYP2D6 (0.45) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4534827 | 0.77 | CYP2D6 (0.44) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4454901 | 0.77 | CYP2D6 (0.42) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 | |
| SCHEMBL4532180 | 0.77 | SIGMAR1 (0.42) | CYP2D6CHRM2CHRM3ALDH1A1CYP3A4 | |
| SCHEMBL4517547 | 0.74 | CYP2D6 (0.40) | CYP2D6CYP2C19CHRM2CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076015-A1 | Tricyclic Spiro Compound Comprising Acyl Group Bound to Nitrogen Atom in the Ring | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076015-A1 | Tricyclic Spiro Compound Comprising Acyl Group Bound to Nitrogen Atom in the Ring | KCNH1, SCN1A, SCN10A | CYP2D6 465/4885CYP2C19 215/4885CHRM2 4608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.