Melengestrol Acetate

Melengestrol Acetate

SCHEMBL4520

C=C1C[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]2(C)[C@@]1(OC(C)=O)C(C)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
TDP1 Q9NUW8 1/20 1.00
PGR P06401 5/20 0.69
AR P10275 5/20 0.69
SMN1; SMN2 Q16637 4/20 0.69
NR3C1 P04150 4/20 0.69
CYP3A4 P08684 4/20 0.69
NPSR1 Q6W5P4 3/20 0.69
CYP2C9 P11712 2/20 0.69
HIF1A Q16665 2/20 0.69
MAPK1 P28482 2/20 0.69
ABCB11 O95342 2/20 0.69
POLB P06746 1/20 0.69
CHRM1 P11229 3/20 0.63
ALDH1A1 P00352 2/20 0.55
CHRM2 P08172 2/20 0.55
USP2 O75604 2/20 0.55
ADORA3 P0DMS8 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Melengestrol Acetate SCHEMBL16389279 1.00 LMNA (1.00) LMNAMEN1KMT2ATDP1PGR
Melengestrol Acetate SCHEMBL15079259 1.00 LMNA (1.00) LMNAMEN1KMT2ATDP1PGR
Melengestrol Acetate SCHEMBL13778228 1.00 LMNA (1.00) LMNAMEN1KMT2ATDP1PGR
Melengestrol Acetate SCHEMBL10867312 1.00 LMNA (1.00) LMNAMEN1KMT2ATDP1PGR
Melengestrol Acetate SCHEMBL31477812 0.95 LMNA (0.91) LMNAMEN1KMT2ATDP1PGR
SCHEMBL30152035 0.90 LMNA (0.81) LMNAMEN1KMT2ATDP1PGR
SCHEMBL30291851 0.90 LMNA (0.81) LMNAMEN1KMT2ATDP1PGR
SCHEMBL8859712 0.88 LMNA (0.78) LMNAMEN1KMT2ATDP1PGR
SCHEMBL9992871 0.87 LMNA (0.77) LMNAMEN1KMT2ATDP1PGR
SCHEMBL8859672 0.87 LMNA (0.77) LMNAMEN1KMT2ATDP1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11391 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-12522572-B2 Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-01-13 US claimed
EP-4647069-A1 DRUGS AND COMPOSITIONS FOR USE IN THE TREATMENT OF RETT SYNDROME UNIVERSITA' DEGLI STUDI DI TRIESTE (IT) 2025-11-12 EP claimed
WO-2025151713-A1 PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS Arkea Bio Corp. (US) 2025-07-17 WO claimed
WO-2025151711-A1 NUCLEIC ACID VACCINES TARGETING METHANOGENS Arkea Bio Corp. (US) 2025-07-17 WO claimed
US-20250222082-A1 PROTEIN AND PEPTIDE VACCINES TARGETING METHANOGENS ARKEA BIO CORP (US) 2025-07-10 US claimed
WO-2025128700-A1 CELL-BASED VACCINES Arkea Bio Corp. (US) 2025-06-19 WO claimed
CN-120118320-A Polyester-based multi-block thermotropic shape memory material with adjustable performance and preparation method thereof 大连理工大学 2025-06-10 CN claimed
WO-2025085377-A1 USE OF ZOALENE IN LIVESTOCK ZOETIS SERVICES LLC (US) 2025-04-24 WO claimed
WO-2025073698-A1 PROCESS FOR BONDING A METALLIC SURFACE WITH ANOTHER SURFACE SPECIALTY OPERATIONS FRANCE (FR) 2025-04-10 WO claimed
US-5112614-A IMPLANTABLE DELIVERY DISPENSER ALZA CORPORATION (US) 1992-05-12 US claimed
EP-0463454-A2 Transdermal administration to humans and animals DERMAMED (IL) 1992-01-02 EP claimed
WO-1991010423-A1 LONG-TERM DELIVERY DEVICE INCLUDING LOADING DOSE ALZA CORPORATION (US) 1991-07-25 WO claimed
WO-1991004016-A1 IMPLANTABLE DELIVERY DISPENSER ALZA CORPORATION (US) 1991-04-04 WO claimed
EP-0179496-A1 16-Sulfinylmethyl-steroids, their preparation and use THE UPJOHN COMPANY (US) 1986-04-30 EP claimed
US-4443377-A Isomerization-acylation process THE UPJOHN COMPANY (US) 1984-04-17 US claimed
EP-0104054-A2 16-methylene-steroids and their preparation THE UPJOHN COMPANY (US) 1984-03-28 EP claimed
US-4346709-A Drug delivery devices comprising erodible polymer and erosion rate modifier ALZA CORPORATION (US) 1982-08-31 US claimed
US-4154748-A Phosphate catalyzed acylation of steroidal tertiary alcohols THE UPJOHN COMPANY (US) 1979-05-15 US claimed
US-3988447-A PALLIATIVE TREATMENT OF ENDOMETRIAL CARCINOMA, PROGESTERONES THE BRITISH DRUG HOUSES LTD. (EN) 1976-10-26 US claimed