Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 5/20 | 0.53 |
| ▸ | AR | P10275 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Melengestrol Acetate SCHEMBL10867312 | 0.87 | LMNA (1.00) | LMNAMEN1KMT2ATDP1PGR | |
| Melengestrol Acetate SCHEMBL13778228 | 0.87 | LMNA (1.00) | LMNAMEN1KMT2ATDP1PGR | |
| Melengestrol Acetate SCHEMBL4520 | 0.87 | LMNA (1.00) | LMNAMEN1KMT2ATDP1PGR | |
| Melengestrol Acetate SCHEMBL15079259 | 0.87 | LMNA (1.00) | LMNAMEN1KMT2ATDP1PGR | |
| Melengestrol Acetate SCHEMBL16389279 | 0.87 | LMNA (1.00) | LMNAMEN1KMT2ATDP1PGR | |
| SCHEMBL30152035 | 0.86 | LMNA (0.81) | LMNAMEN1KMT2ATDP1PGR | |
| SCHEMBL30291851 | 0.86 | LMNA (0.81) | LMNAMEN1KMT2ATDP1PGR | |
| SCHEMBL8859712 | 0.85 | LMNA (0.78) | LMNAMEN1KMT2ATDP1PGR | |
| SCHEMBL9992871 | 0.84 | LMNA (0.77) | LMNAMEN1KMT2ATDP1PGR | |
| SCHEMBL9992866 | 0.84 | LMNA (0.77) | LMNAMEN1KMT2ATDP1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646136-A | ADMINISTERING STEROID HAVING ANGIOSTATIC ACTIVITY TO A PATIENT | DUKE UNIVERSITY (US) | 1997-07-08 | — | — | US | disclosed |