Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.46 |
| ▸ | FNTB | P49356 | 13/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 12/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896396 | 0.84 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL452166 | 0.80 | FNTA (0.37) | FNTAFNTBPGGT1BNPC1RAB9A | |
| SCHEMBL4896990 | 0.79 | FNTA (0.50) | FNTAFNTBPGGT1BNPC1RAB9A | |
| SCHEMBL15125039 | 0.70 | FNTA (0.69) | FNTAFNTBPGGT1B | |
| SCHEMBL4901913 | 0.69 | FNTA (0.49) | FNTAFNTBPGGT1BNPC1RAB9A | |
| SCHEMBL4686868 | 0.68 | ITGB3 (0.43) | — | |
| SCHEMBL11661091 | 0.68 | ACHE (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4900259 | 0.67 | FNTA (0.56) | FNTAFNTBPGGT1B | |
| SCHEMBL4901285 | 0.66 | FNTA (0.56) | FNTAFNTBPGGT1B | |
| SCHEMBL4898703 | 0.65 | FNTA (0.53) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034038-A2 | DUAL INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2012-03-15 | — | — | WO | disclosed |