Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 2/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15124462 | 0.84 | FNTA (0.41) | FNTAFNTBPGGT1BACECTSK | |
| SCHEMBL452165 | 0.80 | FNTA (0.46) | FNTAFNTBPGGT1BNPC1RAB9A | |
| SCHEMBL4686868 | 0.74 | ITGB3 (0.43) | ACEACE2HRH3HRH4 | |
| SCHEMBL4686872 | 0.67 | HRH3 (0.39) | NPC1RAB9ASMN1; SMN2HPGDHRH3 | |
| SCHEMBL8932530 | 0.65 | FAAH (0.51) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL15201783 | 0.65 | MME (0.61) | ACEACE2 | |
| SCHEMBL9936982 | 0.65 | MME (0.61) | ACEACE2 | |
| SCHEMBL2356601 | 0.64 | CYP3A4 (0.50) | NPC1RAB9ASMN1; SMN2HPGDMAPK1 | |
| SCHEMBL8932501 | 0.64 | HDAC1 (0.59) | ACEACE2RAB9AALDH1A1 | |
| SCHEMBL9317172 | 0.63 | POLB (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034038-A2 | DUAL INHIBITORS OF FARNESYLTRANSFERASE AND GERANYLGERANYLTRANSFERASE I | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2012-03-15 | — | — | WO | disclosed |